Stroke / TIA Clinical Trials
Sutter Health participates in clinical trials related to Stroke and TIA throughout their Northern California facilities. See the listing below for an overview of current trials, including contact information. For some trials, more detailed information can be found via the title link to ClinicalTrials.gov.
Title: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) TrialOpens in a new window 
Description: To determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg is effective in preventing major ischemic vascular events at 90 days when subjects are randomized within 12 hours of last known free of symptoms in patients receiving asprin 50-300 mg/day.
Investigator: Wendy Brown, MD
Eligibility: Patients 18 years of age or older with an ABCD2 score > or equal to 4.
Status: Active and open to enrollment
Location: Sutter Medical Center, Sacramento/Sutter Roseville Medical Center
Contact: Theresa Carter (SRMC) 916-781-4036 Email: CarterT3@sutterhealth.org
Barbara Welcher (SMCS) 916-454-6907 Email: WelcheB@sutterhealth.org
Title: Albumin in Acute Stroke (ALIAS) Trial-Part 2: A Phase III, Randomized, Multicenter Clinical Trial of High-Dose Albumin Therapy for Neuroprotection in Acute Ischemic Stroke (National Institute of Neurological Disorders and Stroke) (NINDS, 2U01NS40406-04Opens in a new window
Description: The goal of the trial is to determine whether human albumin, administered within 5 hours of symptom onset, improves the 3-month outcome of subjects with acute ischemic stroke
Investigator: Nobl Barazangi, MD PhD
Eligibility: Acute ischemic stroke with NIHSS >6; able to enroll within 5 hours of stroke onset
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: IV Thrombolysis in Anticoagulated Acute Stroke Patients
Description: Retrospective study of outcomes and safety of patients who receive off-label IV rt-PA despite full anticoagulation
Investigator: Nobl Barazangi, MD PhD
Eligibility: Retrospective
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: Platelet- Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial.Opens in a new window
Description: A prospective randomized double-blind multicenter trial; the primary objective is to determine whether clopidogrel 75mg/day bu mouth after loading dose of 600mg of clopidogrel is effective in preventing major ischemic vascular events ischemic stroke, myocardial infarction, and ischemic vascular death) at 90 days when initiated within 12 hours of TIA or minor ischemic stroke onset in patients receiving aspirin 50-325 mg/day.
Investigator: Nobl Barazangi, MD PhD
Eligibility: TIA or minor stroke; must be enrolled within 12 hours of symptom onset.
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: Expanding the Time Window for IV Thrombolysis with rt-PA in Acute Ischemic Stroke Patients Using Computed Tomography Perfusion Imaging: The PERFusion Use in Stroke Evaluation (PERFUSE) Study (Sutter Pacific Medical Foundation)Opens in a new window
Description: A phase II trial, evaluating the utility of 64 slice CT perfusion (CTP) in acute ischemic stroke (AIS) patients. The main aim is to determine which aspects of CTP imaging can aid in expanding the time window for thrombolysis with IV (rt-PA) in AIS patients up to 6 hours after symptom onset.
Investigator: Nobl Barazangi, MD PhD
Eligibility: Active ischemic stroke within 6 hours of symptom onset received IV rt-PA and have CT perfusion imaging
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: Advancing Telestroke Care: A Prospective Observational StudyOpens in a new window
Description: This study will promote the development and economic sustainability of telemedicine for acute stroke treatment.
Investigator: Nobl Barazangi, MD PhD
Eligibility: Patients treated for acute or subactue ischemic stroke in participating hospitals.
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: Stroke Hyperglycemia Insulin Network Effort (SHINE) TrialOpens in a new window
Description: A multicenter, randomized, controlled clinical trial of 1400 patients. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients with targeted glucose concentration (80mg/dL - 130 mg/dL) will be safe and result in improved 3 month outcome after stroke.
Investigator: Nobl Barazangi, MD PhD
Eligibility: Acute ischemic stroke within 12 hours of stroke onset, with a known history of diabetes or hyperglycemia on admission.
Status: Active and soon open CPMC to enroll
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: A Randomized, Double-Blind, Parallel-Group Placebo-Controlled Phase III Study to Evaluate the Efficacy and Safety of Desmoteplase in Subjects with Acute Ischemic Stroke (DIAS-4) USA (Protocol 12649A Opens in a new window
Description: An efficacy and safety study of desmoteplase in acute ischemic stroke
Investigator: David Bonovich, MD
Eligibility: Adults 18 to 85 years of age. Both genders eligible. Subjects with Acute Ischemic Stroke (AIS) within 9 hours of stroke onset.
Status: Active and open to enrollment
Location: Eden Medical Center
Contact: Lorna Beccaria, RN, CCRC Study Coordinator 510-727-8267
Email: BeccarL@sutterhealth.org
Title: CODMAN Enterprise Vascular Reconstruction Device and Delivery System
Description: Placement of cerebral coils/stents after stroke
Investigator: David Bonovich, MD
Eligibility: Subjects undergoing brain coil/stent placement - Humanitarian use device only
Status: Active and open to enrollment
Location: Eden Medical Center
Contact: Lorna Beccaria, RN, CCRC Study Coordinator 510-727-8267
Email: BeccarL@sutterhealth.org
Title: Neuroform micordelivery Stent System
Description: Placement of cerebral coils/stents after stroke
Investigator: David Bonovich, MD
Eligibility: Subjects undergoing brain coil/stent placement - Humanitarian use device only
Status: Active and open to enrollment
Location: Eden Medical Center
Contact: Lorna Beccaria, RN, CCRC Study Coordinator 510-727-8267
Email: BeccarL@sutterhealth.org
Title: Wingspan Stent System With Gateway PTA Balloon Catheter
Description: Placement of cerebral coils/stents after stroke
Investigator: David Bonovich, MD
Eligibility: Subjects undergoing brain coil/stent placement - Humanitarian use device only
Status: Active and open to enrollment
Location: Eden Medical Center
Contact: Lorna Beccaria, RN, CCRC Study Coordinator 510-727-8267
Email: BeccarL@sutterhealth.org
Title: Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial. Opens in a new window
Description: To determine whether clopidogrel 75 mg/day by mouth after a loading dose of 600 mg is effective in preventing major ischemic vascular events at 90 days when subjects are randomized within 12 hours of TIA in patients receiving aspirin 50-325 mg/day.
Investigator: Frank Kim, MD
Eligibility: Subjects with Transient Ischemic Attack (TIA)
Status: Active and open to enrollment
Location: Eden Medical Center
Contact: Lorna Beccaria, RN, CCRC 510-727-8267
Email: BeccarL@sutterhealth.org
Title: Antihypertensive Treatment of Acute Cerebral Hemorrhage-II (ATACH-II)Opens in a new window
Description: Determine the therapeutic benefit of intensive SBP treatment compared with standard SBP treatment in reducing the proportion of patients with death and disability at day 90 among subjects with ICH treated within 3 hours of symptom onset.
Investigator: Mohammad Mahmood, MD
Eligibility: 18 years and older and less than 90 years. IV nicardipine can be initiatited within 3 hours of symptom onset.
Status: Active and open to enrollment
Location: Sutter Roseville Medical Center
Contact: Theresa Carter 916-781-4036
Email: CarterT3@sutterhealth.org
Title: The S.M.A.R.T. Approach to Stroke Treatment
Description: To evaluate, retrospectively, CPMC's Comprehensive Stroke Care Center's experience with the Simplified Management of Acute stroke using Revised Treatment criteria (SMART) approach towards treating stroke patients
Investigator: David Tong, MD
Eligibility: Retrospective study of all stroke patients treated at CPMC, especially those receiving acute stroke therapy
Status: Active and open to enrollment
Location: California Pacific Medical Center
Contact: Jessica Redford, RN 415-600-1781
Email: RedfordJ@cpmri.org
Title: Phase 1/2A Study of the Safety and Efficacy of Modified Stromal Cells (SB623) in Patients with Stable Ischemic Stroke (Protocol SB-STR01)
Description: The primary objective of this project is to prescreen Sutter neurology patients who have been diagnosed with an ischemic stroke through chart review and visit with physican, to determine if they are eligible for the study titled: “A Phase 1/2A Study of the Safety and Efficacy of Modified Stromal Cells (SB623) in Patients with Stable Ischemic Stroke
Investigator: Gregory LeBleu, MD
Eligibility: Patients 18-75 with a history of one (1) ischemic stroke, who are six (6) months to three (3) years out from Stoke and not improving in medical health.
Status: Active and open to enrollment
Location: Sutter Rehab/SNI/SIMR
Contact: Debbie Jacobs, RN, 916-453-5745
Email: jacobsda@sutterhealth.org
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