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Levonorgestrel-Ethinyl Estrad

Drug Information

Summary of Interactions with Vitamins, Herbs, & Foods

Reference What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

Reference Folic Acid

Oral contraceptive (OC) use can cause folic acid depletion.¹ In a double-blind trial of OC users with Reference cervical dysplasia, supplementation with very large amounts (10 mg per day) of folic acid improved cervical health.² Women with cervical dysplasia diagnosed while they are taking OCs should consult a doctor. Mega-folate supplementation should not be attempted without a doctor’s supervision, nor is there any reason to believe that folic acid supplementation would help people with cervical cancer.
Reference Vitamin B6

Oral contraceptives have been associated with vitamin B6 depletion and clinical Reference depression. In a small, double-blind study of women with depression taking OCs, vitamin B6 (20 mg twice per day) improved depression.³ Half of the women in the study showed laboratory evidence of vitamin B6 deficiency.
Reference Magnesium

Women using OCs were found to have significantly lower serum magnesium levels in a controlled study.⁴ In a preliminary study, blood levels of magnesium decreased in women taking an OC containing ethinyl estradiol and levonorgestrel.⁵ Although the importance of this interaction remains somewhat unclear, supplementation with 250–350 mg of magnesium per day is a safe and reasonable supplemental level for most adults.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Vitamin B1

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁶ ^{, 7} ^{, 8} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁹ ^{, 10} ^{, 11} OCs may interfere with Reference manganese absorption.¹² The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Vitamin B12

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.¹³ ^{, 14} ^{, 15} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.¹⁶ ^{, 17} ^{, 18} OCs may interfere with Reference manganese absorption.¹⁹ The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Vitamin B2

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.²⁰ ^{, 21} ^{, 22} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.²³ ^{, 24} ^{, 25} OCs may interfere with Reference manganese absorption.²⁶ The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Vitamin B3

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.²⁷ ^{, 28} ^{, 29} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.³⁰ ^{, 31} ^{, 32} OCs may interfere with Reference manganese absorption.³³ The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Vitamin C

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.³⁴ ^{, 35} ^{, 36} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.³⁷ ^{, 38} ^{, 39} OCs may interfere with Reference manganese absorption.⁴⁰ The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Reference Zinc

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁴¹ ^{, 42} ^{, 43} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁴⁴ ^{, 45} ^{, 46} OCs may interfere with Reference manganese absorption.⁴⁷ The clinical importance of these actions remains unclear.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

Reference Folic Acid

Oral contraceptive (OC) use can cause folic acid depletion.⁴⁸ In a double-blind trial of OC users with Reference cervical dysplasia, supplementation with very large amounts (10 mg per day) of folic acid improved cervical health.⁴⁹ Women with cervical dysplasia diagnosed while they are taking OCs should consult a doctor. Mega-folate supplementation should not be attempted without a doctor’s supervision, nor is there any reason to believe that folic acid supplementation would help people with cervical cancer.
Reference Vitamin B6

Oral contraceptives have been associated with vitamin B6 depletion and clinical Reference depression. In a small, double-blind study of women with depression taking OCs, vitamin B6 (20 mg twice per day) improved depression.⁵⁰ Half of the women in the study showed laboratory evidence of vitamin B6 deficiency.

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

Reference St. John’s Wort

Eight cases reported to the Medical Products Agency of Sweden suggest that St. John’s wort may interact with oral contraceptives and cause intramenstrual bleeding and/or changes in menstrual bleeding.⁵¹ One reviewer has suggested that St. John’s wort may reduce serum levels of estradiol.⁵² It should be noted, however, that only three of the eight Swedish women returned to normal menstrual cycles after stopping St. John’s wort. Women taking oral contraceptives for birth control should consult with their doctor before taking St. John’s wort.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Explanation Required

Reference Calcium

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁵³ ^{, 54} ^{, 55} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁵⁶ ^{, 57} ^{, 58} OCs may interfere with Reference manganese absorption.⁵⁹ The clinical importance of these actions remains unclear.
Reference Copper

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁶⁰ ^{, 61} ^{, 62} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁶³ ^{, 64} ^{, 65} OCs may interfere with Reference manganese absorption.⁶⁶ The clinical importance of these actions remains unclear.
Reference Iron

Menstrual blood loss is typically reduced with use of OCs. This can lead to increased iron stores and, presumably, a decreased need for iron in premenopausal women.⁶⁷ Premenopausal women taking OCs should have their iron levels monitored and talk with their prescribing doctor before using iron-containing supplements.
Reference Manganese

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁶⁸ ^{, 69} ^{, 70} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁷¹ ^{, 72} ^{, 73} OCs may interfere with Reference manganese absorption.⁷⁴ The clinical importance of these actions remains unclear.
Reference Vitamin A

A review of literature suggests that women who use OCs may experience decreased Reference vitamin B1, Reference B2, Reference B3, Reference B12, Reference C, and Reference zinc levels.⁷⁵ ^{, 76} ^{, 77} OC use has been associated with increased absorption of Reference calcium and Reference copper and with increased blood levels of copper and Reference vitamin A.⁷⁸ ^{, 79} ^{, 80} OCs may interfere with Reference manganese absorption.⁸¹ The clinical importance of these actions remains unclear.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346–53.

2. Butterworth CE Jr, Hatch KD, Gore H, et al. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982 ;35:73–82.

3. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897–904.

4. Olatunbosum DA, Adeniyi FA, Adadevoh BK. Effect of oral contraceptives on serum magnesium levels. Int J Fertil 1974;19:224–6.

5. Blum M, Kitai E, Ariel Y, et al. Oral contraceptive lowers serum magnesium. Harefuah 1991;121:363–4 [in Hebrew].

6. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

7. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

8. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

9. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

10. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

11. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

12. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

13. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

14. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

15. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

16. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

17. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

18. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

19. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

20. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

21. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

22. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

23. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

24. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

25. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

26. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

27. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

28. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

29. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

30. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

31. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

32. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

33. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

34. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

35. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

36. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

37. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

38. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

39. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

40. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

41. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

42. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

43. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

44. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

45. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

46. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

47. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

48. Lindenbaum J, Whitehead N, Reyner F. Oral contraceptive hormones, folate metabolism, and the cervical epithelium. Am J Clin Nutr 1975;28:346–53.

49. Butterworth CE Jr, Hatch KD, Gore H, et al. Improvement in cervical dysplasia associated with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982 ;35:73–82.

50. Adams PW, Wynn V, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraception. Lancet 1973;I:897–904.

51. Safety of St. John’s wort (Hypericum perforatum)[letters to the editor from various authors]. Lancet 2000;355:575–7.

52. Ernst E. Second thoughts about safety of St. John’s wort [letter]. Lancet 1999;354:2014–6.

53. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

54. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

55. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

56. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

57. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

58. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

59. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

60. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

61. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

62. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

63. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

64. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

65. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

66. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

67. Frassinelli-Gunderson EP, Margen S, Brown JR. Iron stores in users of oral contraceptive agents. Am J Clin Nutr 1985;41(4):703.

68. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

69. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

70. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

71. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

72. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

73. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

74. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

75. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

76. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

77. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197–8.

78. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 210–1 [review].

79. Wynn V. Vitamins and oral contraceptive use. Lancet 1975;1:561–4.

80. Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr 1998;52:711–5.

81. Holt GA. Food & Drug Interaction. Chicago: Precept Press, 1998, 197.

Last Review: 11-07-2012

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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