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    Colestipol

    Colestipol



    Drug Information

    Colestipol is a bile acid sequestrant (prevents absorption of bile acids in the digestive system). Bile acids may facilitate the absorption of cholesterol. Colestipol is one of many drugs used to lower cholesterol levels in people with Reference high blood cholesterol.

    Common brand names:

    Colestid, Colestid Flavored

    Summary of Interactions with Vitamins, Herbs, & Foods

    Reference What Are Nutrient Interactions
    Types of interactions: Beneficial Adverse Check

    Replenish Depleted Nutrients

    • Reference Beta-Carotene

      Use of colestipol for six months has been shown to significantly lower blood levels of carotenoids including Reference beta-carotene.1

    • Reference Folic Acid

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.2 , 3 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.4

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 5 Whether these same interactions would occur with colestipol is not known.

    • Reference Vitamin A

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.6 , 7 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.8

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 9 Whether these same interactions would occur with colestipol is not known.

    • Reference Vitamin D

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.10 , 11 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.12

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 13 Whether these same interactions would occur with colestipol is not known.

    • Reference Vitamin E

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.14 , 15 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.16

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 17 Whether these same interactions would occur with colestipol is not known.

    • Reference Vitamin K

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.18 , 19 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.20

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 21 Whether these same interactions would occur with colestipol is not known.

    • Reference Calcium

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.22 , 23 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.24

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 25 Whether these same interactions would occur with colestipol is not known.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
    • Reference Carotenoids

      Use of colestipol for six months has been shown to significantly lower blood levels of carotenoids including Reference beta-carotene.26

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
    • Reference Zinc

      Bile acid sequestrants, including colestipol, may prevent absorption of Reference folic acid and the fat-soluble vitamins Reference A, Reference D, Reference E, Reference K.27 , 28 People taking colestipol should consult with their doctor about vitamin malabsorption and supplementation. People should take other drugs and vitamin supplements one hour before or four to six hours after colestipol to improve absorption.29

      Animal studies suggest Reference calcium and Reference zinc may be depleted by taking cholestyramine, another bile acid sequestrant. 30 Whether these same interactions would occur with colestipol is not known.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

    Reduce Side Effects

    • Reference Milk Thistle

      Milk thistle’s (Silybum marianum) major flavonoids, known collectively as silymarin, have shown synergistic actions with the chemotherapy drugs Reference cisplatin and Reference doxorubicin (Adriamycin®) in test tubes.31 Silymarin also offsets the kidney toxicity of cisplatin in animals.32 Silymarin has not yet been studied in humans treated with cisplatin. There is some evidence that silymarin may not interfere with some chemotherapy in humans with cancer.33

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

    Support Medicine

    • none

    Reduces Effectiveness

    • none

    Potential Negative Interaction

    • none

    Explanation Required 

    • none

    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

    References

    1. Probstfield JL, Lin T, Peters J, Hunninghake DB. Carotenoids and vitamin A: The effect of hypocholesterolemic agents on serum levels. Metabolism 1985;34:88–91.

    2. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    3. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    4. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    5. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    6. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    7. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    8. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    9. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    10. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    11. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    12. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    13. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    14. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    15. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    16. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    17. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    18. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    19. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    20. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    21. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    22. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    23. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    24. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    25. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    26. Probstfield JL, Lin T, Peters J, Hunninghake DB. Carotenoids and vitamin A: The effect of hypocholesterolemic agents on serum levels. Metabolism 1985;34:88–91.

    27. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 224 [review].

    28. Threlkeld DS, ed. Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    29. Threlkeld DS(ed). Cardiovascular Drugs, Antihyperlipidemic Agents, Bile Acid Sequestrants. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Feb 1999, 171L.

    30. Watkins DW, Cassidy MM, Khalafi R, Vahouny GV. Calcium and zinc balances in rats chronically fed the bile salt-sequestrant cholestyramine (Questran). Fed Proc 1983;42:819.

    31. Scambia G, De Vincenzo R, Ranelletti FO, et al. Antiproliferative effect of silybin on gynaecological malignancies: Synergism with cisplatin and doxorubicin. Eur J Cancer 1996;32A:877–82.

    32. Gaedeke J, Fels LM, Bokemeyer C, et al. Cisplatin nephrotoxicity and protection by silibinin. Nephrol Dial Transplant 1996;11:55–62.

    33. Invernizzi R, Bernuzzi S, Ciani D, Ascari E. Silymarine during maintenance therapy of acute promyelocytic leukemia. Haemotologia 1993;78:340–1.

    Last Review: 11-07-2012

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