Hydroxychloroquine is used to prevent and treat acute attacks of malaria and to treat both acute and chronic Reference rheumatoid arthritis and Reference lupus. It is in a class of drugs known as antimalarials.
Common brand names:Plaquenil
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
An individual who took hydroxychloroquine and vitamin B6 together for nine years experienced a complete disappearance of skin nodules caused by Reference rheumatoid arthritis.1 Controlled study is needed to determine whether taking vitamin B6 with or without hydroxychloroquine might help eliminate nodules in people with rheumatoid arthritis.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Magnesium supplementation may reduce blood levels of chloroquine, a compound similar to hydroxychloroquine, and decrease its effectiveness.2 Until more is known, people taking hydroxychloroquine for arthritis who are also using magnesium supplements and are not experiencing relief might try avoiding the supplements or taking them at separate times.The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.
Potential Negative Interaction
1. McCarty DJ. Complete reversal of rheumatoid nodulosis. J Rheumatology 1991;18:736–7.
2. Olin BR, ed. Anti-infectives, Antimalarial Preparations, 4-Aminoquinoline Compounds. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, 1993, 1913–6.
Last Review: 11-07-2012
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