Health Information

Fenofibrate

Drug Information

Fenofibrate is used to lower elevated Reference cholesterol and Reference triglyceride levels when diet, exercise, and weight loss programs are ineffective. It is in a family of medications known as cholesterol-lowering drugs.

Common brand names:

Antara, Tricor

Summary of Interactions with Vitamins, Herbs, & Foods

Reference What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

none

Reduce Side Effects

Reference Folic Acid

Increased blood levels of Reference homocysteine are associated with increased risk of Reference atherosclerosis and Reference heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced.¹ In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy.² Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Reference Vitamin B12

Increased blood levels of Reference homocysteine are associated with increased risk of Reference atherosclerosis and Reference heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced.³ In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy.⁴ Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Reference Vitamin B6

Increased blood levels of Reference homocysteine are associated with increased risk of Reference atherosclerosis and Reference heart disease. One study revealed that fenofibrate dramatically increases blood homocysteine levels, though blood levels of vitamins were not reduced.⁵ In one study, supplementation with 10 mg per day of folic acid prevented the increase in homocysteine levels resulting from fenofibrate therapy.⁶ Further research is needed to determine whether supplemental vitamin B6 and vitamin B12, which are also capable of lowering homocysteine levels, might lower fenofibrate-induced elevations in homocysteine levels.
Vitamin C and Vitamin E

Several studies have shown that fenofibrate enhances the toxic effect of ultraviolet (UV) radiation from the sun, which might result in side effects such as skin rashes. One controlled study showed that taking 2 grams of vitamin C and 1,000 IU of vitamin E prior to ultraviolet exposure dramatically blocked UV-fenofibrate damage to red blood cells.⁷ though further controlled studies are needed, people taking fenofibrate should probably supplement with vitamins C and E until more information is available.

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219–20.

2. Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367–71.

3. Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219–20.

4. Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367–71.

5. Dierkes J, Westphal S, Luley C. Serum homocysteine increases after therapy with fenofibrate or bezafibrate. Lancet 1999;354:219–20.

6. Mayer O Jr, Simon J, Holubec L, et al. Fenofibrate-induced hyperhomocysteinemia may be prevented by folate co-administration. Eur J Clin Pharmacol 2003;59:367–71.

7. Eberlein-Konig B, Placzek M, Przybilla B. Phototoxic lysis of erythrocytes from humans is reduced after oral intake of ascorbic acid and d-alpha-tocopherol. Photodermatol Photoimmunol Photomed 1997;13:173–7.

Last Review: 11-07-2012

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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