Health Information

Ranitidine

Drug Information

Ranitidine is a member of the H-2 (histamine blocker) family of drugs, which prevents the release of acid into the stomach. Ranitidine is used to treat stomach and duodenal Reference ulcers, gastroesophageal reflux disease, erosive esophagitis, and Zollinger-Ellison syndrome. Ranitidine is available as a prescription drug and also as a nonprescription over-the-counter product for relief of Reference heartburn.

Common brand names:

Zantac, Zantac 150 Maximum Strength, Zantac 75

Summary of Interactions with Vitamins, Herbs, & Foods

Reference What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

Reference Folic Acid

Folic acid is needed by the body to utilize Reference vitamin B12. Antacids, including ranitidine, inhibit folic acid absorption.¹ People taking antacids are advised to supplement with folic acid.
Reference Iron

Stomach acid may facilitate iron absorption. H-2 blocker drugs reduce stomach acid and are associated with decreased dietary iron absorption.² People with ulcers may also be iron deficient due to blood loss and benefit from iron supplementation. Iron levels in the blood can be checked with lab tests.
Reference Vitamin B12

Stomach acid is needed to release vitamin B12 from food so it can be absorbed by the body. H-2 blocker drugs reduce stomach acid and are associated with decreased dietary vitamin B12 absorption.³ The vitamin B12 found in supplements is available to the body without the need for stomach acid. Lab tests can determine vitamin B12 levels.

The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

Reduce Side Effects

none

Support Medicine

none

Reduces Effectiveness

none

Potential Negative Interaction

none

Explanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Russell RM, Golner BB, Krasinski SD, et al. Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid. J Lab Clin Med 1988;112:458–63.

2. Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430–48.

3. Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430–48.

Last Review: 11-07-2012

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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