Health Information

Gemifloxacin

Drug Information

Gemifloxacin is used to treat bacterial infections, such as chronic Reference bronchitis and mild to moderate pneumonia.

Common brand names:

Factive

Summary of Interactions with Vitamins, Herbs, & Foods

Reference What Are Nutrient Interactions

Types of interactions: Beneficial Adverse Check

Replenish Depleted Nutrients

none

Reduce Side Effects

none

Support Medicine

none

Reduces Effectiveness

Reference Calcium

A recent study showed that taking calcium carbonate and gemifloxacin at the same time results in a significant reduction in blood levels of the drug.¹ Consequently, gemifloxacin and calcium supplements should not be taken at the same time.
Reference Iron

A review of interactions involving quinolone antibiotics indicated that supplements containing iron, when taken at the same time as gemifloxacin, might reduce absorption of the drug up to 50%.² Consequently, gemifloxacin and supplements containing iron should not be taken at the same time.
Reference Magnesium

One study showed that taking an antacid containing magnesium and aluminum ten minutes before gemifloxacin results in an 85% reduction in the absorption of the drug.³ Consequently, gemifloxacin and supplements containing magnesium should not be taken at the same time.

Potential Negative Interaction

none

Explanation Required

none

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

References

1. Allen A, Vousden M, Porter A, Lewis A. Effect of Maalox on the bioavailability of oral gemifloxacin in healthy volunteers. Chemotherapy 1999;45:504–11.

2. Lode H. Evidence of different profiles of side effects and drug-drug interactions among the quinolones—the pharmacokinetic standpoint. Chemotherapy 2001;47 Suppl 3:24–31; discussion 44–8.

3. Pletz MW, Petzold P, Allen, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158–60.

Last Review: 11-07-2012

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2013.

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