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    Inherited Blood-Clotting Problems

    Inherited Blood-Clotting Problems

    Topic Overview

    Some people are born with an increased tendency to form blood clots, which increases their risk for developing blood clots in the legs ( deep vein thrombosis ) and in the lungs ( pulmonary embolism ). This tendency is due to inherited blood-clotting irregularities, which are generally related to:

    • Mutated genes (such as factor V Leiden, factor II).
    • Decreased amounts of certain proteins (protein C, protein S, and antithrombin III).
    • Increased levels of other substances (antiphospholipid or lupus anticoagulant).

    Many of these blood-clotting irregularities can be identified with special tests. If your doctor suspects that you may have an inherited blood-clotting irregularity, discuss whether testing is needed.

    Related Information

    References

    Other Works Consulted

    • Lipe B, Ornstein DL (2011). Deficiencies of natural anticoagulants, protein C, protein S, and antithrombin. Circulation, 124(14): e365?e368.

    Credits

    By Healthwise Staff
    Primary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine
    Specialist Medical Reviewer Jeffrey S. Ginsberg, MD - Hematology
    Last Revised December 28, 2011

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