Medicines for Erection Problems: Reactions With Nitrate

Phosphodiesterase-5 inhibitors, such as sildenafil (for example, Viagra), have revolutionized the treatment of Reference erection problems Opens New Window (erectile dysfunction). But they can cause life-threatening side effects for anyone who also takes nitroglycerin or another medicine containing an organic nitrate. This combination can make your blood pressure fall too low, possibly leading to a Reference stroke Opens New Window, a Reference heart attack Opens New Window, or death. Do not take nitrate-containing medicines up to 24 hours after you take sildenafil (for example, Viagra) or vardenafil (for example, Levitra), or up to 48 hours after you take tadalafil (for example, Cialis).

Medicines that contain organic nitrates include:

• Nitroglycerin (such as Nitro-Dur, Nitrolingual, Nitrostat).
• Isosorbide (such as Dilatrate, Isordil).
• Nitroprusside (such as Nitropress).
• Amyl nitrite or amyl nitrate (sometimes called "poppers"), which are sometimes abused.

Nitrates found in foods are not a danger when taking phosphodiesterase-5 inhibitors.

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