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    Cirrhosis: Vasoconstrictor Medicines for Variceal Bleeding

    Cirrhosis: Vasoconstrictor Medicines for Variceal Bleeding

    Topic Overview

    Medicines that constrict small blood vessels and reduce blood flow to the portal vein are used to treat sudden (acute) bleeding from enlarged veins (varices) in the digestive tract (variceal bleeding).

    Octreotide is the main medicine used in the United States to treat variceal bleeding.

    These medicines also may be used along with endoscopic treatment. Adding medicine to endoscopic treatment works better to control bleeding than endoscopic treatment alone. 1

    Side effects of these medicines may include:

    • Irregular heartbeats (arrhythmias).
    • Headache.
    • Dizziness.
    • Too much sugar in the blood (hyperglycemia).
    • Diarrhea.
    • Formation of gallstones (with long-term use).

    References

    Citations

    1. Garcia-Tsao G, et al. (2007). Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. American Journal of Gastroenterology, 102(9): 2086?2102.

    Credits

    By Healthwise Staff
    Primary Medical Reviewer Adam Husney, MD - Family Medicine
    Specialist Medical Reviewer W. Thomas London, MD - Hepatology
    Last Revised January 17, 2012

    Last Revised: January 17, 2012

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