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    Huperzia

    Huperzia

    Uses

    Common names:
    Huperzine, Qian Ceng Ta
    Botanical names:
    Huperzia serrata

    Parts Used & Where Grown

    Huperzia is a type of moss that grows in China. It is related to club mosses (the Lycopodiaceae family) and is known to some botanists as Lycopodium serratum. The whole prepared moss was used traditionally. Modern herbal preparations use only the isolated alkaloid known as huperzine A.

    What Are Star Ratings?

    Our proprietary ?Star-Rating? system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

    For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

    3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.

    2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

    1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

    This supplement has been used in connection with the following health conditions:

    Used for Why
    2 Stars
    Age-Related Cognitive Decline
    100 to 150 mcg two to three times per day
    Huperzine A, an extract from a Chinese medicinal herb, has been found to improve cognitive function in seniors with memory disorders.

    Huperzine A, an isolated alkaloid from the Chinese medicinal herb huperzia (Huperzia serrata), has been found to improve cognitive function in elderly people with memory disorders. One double-blind trial found that huperzine A (100 to 150 mcg two to three times per day for four to six weeks) was more effective for improving minor memory loss associated with ARCD than the drug piracetam.2 More research is needed before the usefulness of huperzine A is confirmed for mild memory loss associated with ARCD.

    2 Stars
    Alzheimer?s Disease
    200 mcg of huperzine A twice per day
    Huperzine A, a substance found in the Chinese medicinal herb huperzia (Huperzia serrata), has been shown to improve memory and mental and behavioral function in people with dementia, including Alzheimer?s disease.

    Huperzine A is a substance found in huperzia  (Huperzia serrata), a Chinese medicinal herb. In a placebo-controlled trial, 58% of people with Alzheimer?s disease had significant improvement in memory and mental and behavioral function after taking 200 mcg of huperzine A twice per day for eight weeks?a statistically significant improvement compared to the 36% who responded to placebo.3 Another double-blind trial using injected huperzine A confirmed a positive effect in people with dementia, including, but not limited to, Alzheimer?s disease.4 Yet another double-blind trial found that huperzine A, given at levels of 100 to 150 mcg two to three times per day for four to six weeks, was more effective at improving minor memory loss associated with age-related cognitive decline than the drug piracetam.5 This study found that huperzine A was not effective in relieving symptoms of Alzheimer?s disease. Clearly, more research is needed before the usefulness of huperzine A for Alzheimer?s disease is confirmed.

    Traditional Use (May Not Be Supported by Scientific Studies)

    Huperzia moss tea has been used for centuries in traditional Chinese herbalism for fever, as a diuretic, for blood loss, and for irregular menstruation.1

    How It Works

    Common names:
    Huperzine, Qian Ceng Ta
    Botanical names:
    Huperzia serrata

    How It Works

    Huperzine A is an alkaloid found in huperzia that has been reported to prevent the breakdown of acetylcholine, an important substance needed by the nervous system to transmit information from cell to cell.6 Animal research has suggested that huperzine A?s ability to preserve acetylcholine may be greater than that of some prescription drugs.7 , 8 Loss of acetylcholine function is a primary feature of several disorders of brain function, including Alzheimer?s disease . Huperzine A may also have a protective effect on brain tissue, further increasing its theoretical potential for helping reduce symptoms of some brain disorders.9 , 10

    In a double-blind trial, people with Alzheimer?s disease had significant improvement in memory and cognitive and behavioral functions after taking 200 mcg of huperzine A twice per day for eight weeks.11 Another double-blind trial using injected huperzine A confirmed a positive effect in people with dementia, including, but not limited to, Alzheimer?s disease.12 Another double-blind trial found that huperzine A (100?150 mcg two to three times per day for four to six weeks) was more effective for improving minor memory loss associated with age-related cognitive decline than the drug piracetam.13

    Huperzine A has also been shown to enhance memory in adolescent middle school students. A small controlled trial found that 100 mcg of huperizine A two times per day for four weeks was effective in improving memory and learning performance.14 Although no side effects were reported in this short trial, long-term safety studies are needed before huperizine A is recommended for adolescents or younger children to improve memory and learning performance.

    How to Use It

    Human research on huperzine A has used 100?200 mcg taken two to three times per day.15

    Interactions

    Common names:
    Huperzine, Qian Ceng Ta
    Botanical names:
    Huperzia serrata

    Interactions with Supplements, Foods, & Other Compounds

    At the time of writing, there were no well-known supplement or food interactions with this supplement.

    Interactions with Medicines

    Certain medicines interact with this supplement.

    Types of interactions: Beneficial Adverse Check

    Replenish Depleted Nutrients

    • none

    Reduce Side Effects

    • none

    Support Medicine

    • none

    Reduces Effectiveness

    • none

    Potential Negative Interaction

    • Donepezil

      Further studies are needed to determine the long-term safety of huperizine A. Until more is known about it?s actions in the body, it is best to avoid using it together with donepezil, which also prevents the breakdown of acetylcholine.

      The interaction is supported by preliminary, weak, fragmentary, and/or contradictory scientific evidence.

    Explanation Required

    • none

    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers? package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

    Side Effects

    Common names:
    Huperzine, Qian Ceng Ta
    Botanical names:
    Huperzia serrata

    Side Effects

    Medications that prevent acetylcholine breakdown often produce side effects, including nausea, vomiting, excess saliva and tear production, and sweating. However, while dizziness was reported in a few people in one study, no severe side effects have been reported in human trials using huperzine A. Further studies are needed to determine the long-term safety of huperzine A.

    References

    1. Kozikowski AP, Tückmantel W. Chemistry, Pharmacology, and Clinical Efficacy of the Chinese Nootropic Agent Huperzine A. www.huperzine.net/invent.htm, 26 June 2000.

    2. Wang Z, Ren G, Zhao Y, et al. A double-blind study of huperzine A and piracetam in patients with age-associated memory impairment and dementia. In: Kanba S, Richelson E, eds. Herbal Medicines for Nonpsychiatric Diseases. Tokyo: Seiwa Shoten Publishers, 1999, 39?50.

    3. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer?s disease. Chung Kuo Yao Li Hsueh Pao 1995;16:391?5.

    4. Zhang RW, Tang XC, Han YY, et al. Drug evaluation of huperzine A in the treatment of senile memory disorders. Chung Kuo Yao Li Hsueh Pao 1991;12:250?2 [in Chinese].

    5. Wang Z, Ren G, Zhao Y, et al. A double-blind study of huperzine A and piracetam in patients with age-associated memory impairment and dementia. In: Kanba S, Richelson E, eds. Herbal Medicines for Nonpsychiatric Diseases. Tokyo: Seiwa Shoten Publishers, 1999, 39?50.

    6. Ashani Y, Peggins JO, Doctor BP. Mechanism of inhibition of cholinesterases by huperzine A. Biochem Biophys Res Commun 1992;184:719?26.

    7. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998;60:377?86.

    8. Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 1996;8:97?101.

    9. Ved HS, Koenig ML, Dave JR, et al. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport 1997;8:963?8.

    10. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer?s disease therapy [news item]. JAMA 1997;277:776.

    11. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer?s disease. Chung Kuo Yao Li Hsueh Pao 1995;16:391?5.

    12. Zhang RW, Tang XC, Han YY, et al. Drug evaluation of huperzine A in the treatment of senile memory disorders. Chung Kuo Yao Li Hsueh Pao 1991;12:250?2 [in Chinese].

    13. Wang Z, Ren G, Zhao Y, et al. A double-blind study of huperzine A and piracetam in patients with age-associated memory impairment and dementia. In: Kanba S, Richelson E (eds). Herbal Medicines for Nonpsychiatric Diseases. Tokyo: Seiwa Shoten Publishers, 1999, 39?50.

    14. Sun QQ, Xu SS, Pan JL, et al. Huperizine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Acta Pharmacol Sin 1999;20:601?3.

    15. Qian BC, Wang M, Zhou ZF, et al. Pharmacokinetics of tablet huperzine A in six volunteers. Chung Kuo Yao Li Hsueh Pao 1995;16:396?8.

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