Selective Serotonin Reuptake Inhibitors (SSRIs) for Postpartum Depression

SSRIs make bleeding more likely in the upper gastrointestinal tract (stomach and esophagus). Taking SSRIs with NSAIDs (such as Advil or Aleve) makes bleeding even more likely. Taking medicines that control acid in the stomach may help.^{Reference 1}

All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

• Usually the benefits of the medicine are more important than any minor side effects.
• Side effects may go away after you take the medicine for a while.
• If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

• Trouble breathing.
• Swelling of your face, lips, tongue, or throat.

Call your doctor if you have:

• Hives.
• Thoughts of suicide.
• Agitation and restlessness.
• Seizures.
• Fast heartbeat.
• Nausea and vomiting.

Common side effects of this medicine include:

• Loss of sexual desire or ability.
• Irritability.
• Trouble sleeping or drowsiness.
• Headache.
• Changes in appetite.

The U.S. Food and Drug Administration (FDA) has issued an Reference advisory on antidepressant medicines and the risk of suicide. Talk to your doctor about these possible side effects and the Reference warning signs of suicide.

The FDA has also issued a warning about taking triptans, used for headaches, with SSRIs (selective serotonin reuptake inhibitors) or SNRIs (selective serotonin/norepinephrine reuptake inhibitors). Taking these medicines together can cause a very rare but serious condition called serotonin syndrome.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

© 1995-2011, Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.

This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Reference Terms of Use. Reference How this information was developed to help you make better health decisions.