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    Generic Name Brand Name
    procarbazine Matulane

    Procarbazine is given in pill form.

    How It Works

    Procarbazine is classified as an alkylating agent. It causes cell death by interfering with the way genetic material (DNA) in the cell multiplies.

    Why It Is Used

    Procarbazine is used to treat leukemia and non-Hodgkin's lymphoma. It may also be used to treat other kinds of cancer.

    How Well It Works

    Procarbazine is an effective treatment for non-Hodgkin's lymphoma.

    Side Effects

    Side effects of procarbazine are common, generally mild, and may include:

    • Nausea or vomiting.
    • Loss of appetite.
    • Mouth sores (stomatitis).
    • Changes in the way things taste.
    • Cough or shortness of breath.
    • Tingling or numbness of fingers or toes (peripheral neuropathy).
    • Skin rash, which may itch.
    • Diarrhea.

    Women who take this medicine may experience menopausal symptoms, including hot flashes and vaginal dryness.

    See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

    What To Think About

    Procarbazine should be given only under the supervision of a medical oncologist or hematologist .

    Procarbazine can affect your ability to have children. You may not be able to become pregnant or father a child after taking procarbazine. Discuss fertility with your doctor before starting treatment with this medicine.

    Procarbazine can cause birth defects. Do not use this medicine if you are pregnant or wish to become pregnant or father a child while you are taking it.

    Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.


    By Healthwise Staff
    Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
    Specialist Medical Reviewer Douglas A. Stewart, MD - Medical Oncology
    Last Revised March 29, 2012

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