OxaliplatinSkip to the navigation
Common brand names:Eloxatin
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
Reduce Side Effects
Calcium and Magnesium
In a double-blind trial, intravenous administration of calcium and magnesium before and after administration of oxaliplatin prevented the development of oxaliplatin-induced nerve damage.1 However, in another double-blind trial, the same treatment regimen as in the other study did not prevent oxaliplatin-induced nerve damage.2 It is not known whether oral administration of these minerals would also be beneficial.
Potential Negative Interaction
1. Grothey A, Nikcevich DA, Sloan JA, et al. Intravenous calcium and magnesium for oxaliplatin-induced sensory neurotoxicity in adjuvant colon cancer: NCCTG N04C7. J Clin Oncol 2011;29:421-7.
2. Loprinzi CL, Qin R, Dakhil SR, et al. Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance). J Clin Oncol2013 Dec 2 [Epub ahead of print].
Last Review: 03-24-2015
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