CerivastatinSkip to the navigation
Caution: On August 8, 2001, Bayer Pharmaceutical Division voluntarily withdrew Baycol (cerivastatin) from the US market because of reports of sometimes fatal rhabdomyolysis, a severe muscle adverse reaction from this cholesterol-lowering (lipid-lowering) product. Bayer is taking similar action in other countries except Japan.
Cerivastatin is used to lower elevated blood cholesterol and triglyceride levels when low-fat diets and lifestyle changes are ineffective. It is in a family of drugs known as HMG-CoA reductase inhibitors.
Common brand names:Baycol
Summary of Interactions with Vitamins, Herbs, & Foods
Replenish Depleted Nutrients
In a group of patients beginning treatment with atorvastatin, the average concentration of coenzyme Q10 in blood plasma decreased within 14 days, and had fallen by approximately 50% after 30 days of treatment.1 Many doctors recommend CoQ10 supplementation to prevent the drug-induced decline in CoQ10 levels.
Reduce Side Effects
In a preliminary study, supplementation with 100 mg of CoQ10 per day reduced the severity of muscle pain by 40% in people with muscle pain caused by a statin drug.2 A double-blind trial also found that CoQ10 (200 mg per day) significantly decreased drug-induced muscle symptoms in people taking statin drugs.3
However, in another double-blind trial, CoQ10 in the amount of 60 mg twice a day for one month was not more effective than a placebo for relieving muscle pain.4 Although the evidence is conflicting regarding whether supplementing with CoQ10 relieves statin-induced muscle symptoms, many doctors recommend CoQ10 supplementation to prevent the drug-induced decline in CoQ10 levels.
Potential Negative Interaction
Vitamin B3 (Niacin)
Some sources have reported that taking niacin (vitamin B3) together with HMG-CoA reductase inhibitors may result in serious muscle damage.5 However, niacin has also been used in combination with statin drugs without ill effects, and has been found to enhance the cholesterol-lowering effect of these drugs.6 , 7 Persons taking cerivastatin or any other HMG-CoA reductase inhibitor should consult with their doctor before taking niacin.
1. Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol 2004;61:889-92.
2. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am J Cardiol 2007;99:1409-12.
3. Fedacko J, Pella D, Fedackova P, et al. Coenzyme Q10 and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol2013;91:165-70.
4. Bookstaver DA, Burkhalter NA, Hatzigeorgiou C. Effect of coenzyme Q10 supplementation on statin-induced myalgias. Am J Cardiol 2012;110:526-9.
5. Sifton DW, et. Physicians' Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 675-7.
6. Davignon J, Roederer G, Montigny M, et al. Comparative efficacy and safety of pravastatin, Nicotinic acid and the two combined in patients with hypercholesterolemia. Am J Cardiol 1994;73:339-45.
7. Jacobson TA, Jokubaitis LA, Amorosa LF. Fluvastatin and niacin in hypercholesterolemia: a preliminary report on gender differences in efficacy. Am J Med 1994;96(suppl 6A):64S-8S.
Last Review: 04-29-2014
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