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    Sodium Fluoride

    Sodium Fluoride

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    Drug Information

    Sodium fluoride is used to prevent dental cavities and might be effective in the treatment of osteoporosis .

    Common brand names:

    Fluor-A Day, Luride, PreviDent, ACT Fluoride, EtheDent, Gel-Kam, Karigel, Pediaflor

    Summary of Interactions with Vitamins, Herbs, & Foods

    Types of interactions: Beneficial Adverse Check

    Replenish Depleted Nutrients

    • Zinc

      Individuals who are bedridden for long periods may become deficient in zinc, which can affect the strength of bone that is formed. In a controlled study of healthy adults who were confined to bed, fluoride supplementation prevented zinc loss from the body.1 Bedridden individuals should consult a qualified healthcare practitioner for guidance in using fluoride to prevent zinc deficiency.

    Reduce Side Effects

    • none

    Support Medicine

    • Vitamin D

      Collagen is a protein that is used in many areas of the body for structural support. One test tube study showed that the active form of vitamin D, 1,25 dihydroxycholecalciferol, increased the production of a certain type of collagen when it was combined with fluoride.2 Controlled research is needed to determine whether taking 1,25 dihydroxycholecalciferol with sodium fluoride might promote beneficial collagen growth.

    • Vitamin E

      Vitamin E increases the resistance of tooth enamel to acids that cause cavities, and test tube studies show that fluoride, when added to vitamin E, enhances this effect.3 Controlled research is needed to determine whether people might develop fewer cavities when taking vitamin E and fluoride together.

    Reduces Effectiveness

    • none

    Potential Negative Interaction

    • none

    Explanation Required 

    • Calcium

      Research shows that calcium from leg bones may be transferred to bones in the spine causing stress fractures when fluoride is taken alone. However, supplementing with 1,500 mg of calcium each day together with slow-release forms of fluoride increases the bone density of the lumbar spine without causing fractures.4 Therefore, people taking sodium fluoride to treat osteoporosis should probably supplement with calcium to prevent this adverse effect. However, taking fluoride and calcium at the same time significantly reduces the absorption of fluoride;5 consequently, they should be taken at least an hour apart.

    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.


    1. Krebs JM, Schneider VS, LeBlanc AD. Zinc, copper and nitrogen balance during bed rest and fluoride supplementation in healthy adult males. Am J Clin Nutr 1998;47:509-14.

    2. Kassem M, Mosekilde L, Eriksen EF. 1,25-dihydroxy-vitamin D3 potentiates fluoride-stimulated collagen Type I production in cultures of human bone marrow stromal osteoblast-like cells. J Bone Miner Res 1993;8:1453-8.

    3. Yu H, Oho T, Xu LX. Effects of several tea components on acid resistance of human tooth enamel. J Dent 1995;23:101-5.

    4. Deal CL. Osteoporosis: prevention, diagnosis, and management. Am J Med 1997;102:35s-9s.

    5. Ekstrand J, Spak CJ. Fluoride pharmacokinetics: its implication in the fluoride treatment of osteoporosis. J Bone Miner Res 1990;5 Suppl 1:s53-61.

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