These antibody tests are often positive in lupus and can
provide support for a diagnosis if the clinical criteria are unclear or if the
ANA test is negative but lupus is strongly suspected.
Anti-SS-A (Ro) and anti-SS-B (La) antibodies are
not specific for lupus and are found commonly in
Sjögren's syndrome. But these tests are useful in
helping women with lupus who are considering pregnancy. If a woman who has
these antibodies becomes pregnant, she may need more careful monitoring of the
fetus, since these antibodies are associated with a higher risk of the baby
being born with neonatal lupus syndrome or a heart defect called congenital
High titers of anti-dsDNA
are usually seen only in people who have lupus.
A positive anti-Sm test is a specific marker for lupus.
Anti-dsDNA tests can be repeated at intervals to monitor how
the disease is progressing.