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    Vitamin B2

    Uses

    Vitamin B2 is a water-soluble vitamin needed to process amino acids and fats, activate vitamin B6 and folic acid , and help convert carbohydrates into the fuel the body runs on-adenosine triphosphate (ATP). Under some conditions, vitamin B2 can act as an antioxidant .

    What Are Star Ratings?

    Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

    For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

    3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.

    2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

    1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

    This supplement has been used in connection with the following health conditions:

    Used for Why
    3 Stars
    Anemia
    5 to 30 mg daily in divided doses
    Vitamin B2 deficiency can contribute to anemia, supplementing with this vitamin may restore levels and improve symptoms.

    Deficiencies of iron , vitamin B12 , and folic acid are the most common nutritional causes of anemia. Although rare, severe deficiencies of several other vitamins and minerals, including vitamin A ,vitamin B2, vitamin B6 , vitamin C , and copper , can also cause anemia by various mechanisms. Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as vitamin B1 .

    3 Stars
    Migraine Headache (For adults only )
    400 mg daily
    Studies have shown vitamin B2 to be effective at reducing the frequency and severity of migraine headaches.

    One group of researchers treated 49 migraine patients with large amounts of vitamin B2 (400 mg per day). Both the frequency and severity of migraines decreased by more than two-thirds. In a follow-up three-month, double-blind trial, the same researchers reported that 59% of patients assigned to receive vitamin B2 had at least a 50% reduction in the number of headache days, whereas only 15% of those assigned to receive a placebo experienced that degree of improvement. The effects of vitamin B2 were most pronounced during the final month of the trial. In a preliminary study, a much smaller amount of vitamin B2 (25 mg per day for three months) reduced the frequency of migraines by about one-third in chronic migraine sufferers.

    All of the studies that found riboflavin to be effective for preventing migraine were conducted in adults. In a double-blind trial, supplementation with 200 mg per day of riboflavin did not decrease the frequency or severity of migraines in children whose average age was 11 years.

    2 Stars
    Cataracts
    3 mg daily with 40 mg daily vitamin B3
    Vitamin B2 is needed to protect glutathione, an important antioxidant in the eye. In one study, supplementing with vitamin B2 prevented cataracts in people who were deficient.

    People with low blood levels of antioxidants and those who eat few antioxidant-rich fruits and vegetables have been reported to be at high risk for cataracts.

    Vitamin B2 and vitamin B3 are needed to protect glutathione , an important antioxidant in the eye. Vitamin B2 deficiency has been linked to cataracts. Older people taking 3 mg of vitamin B2 and 40 mg of vitamin B3 per day were partly protected against cataracts in one trial. However, the intake of vitamin B2 in China is relatively low, and it is not clear whether supplementation would help prevent cataracts in populations where vitamin B2 intake is higher.

    2 Stars
    High Homocysteine
    1.6 mg daily
    Vitamin B2 (riboflavin) supplementation has been shown to lower homocysteine levels in certain people.

    Vitamin B2 (riboflavin) supplementation (1.6 mg per day) has been shown to lower homocysteine levels by 22 to 40% in a subset of the population that has a certain genetic variant of an enzyme involved in folic acid metabolism (the 677Cà T polymorphism for the methylenetetrahydrofolate reductase gene). Approximately 15 to 20% of the population carries this gene and could benefic from taking riboflavin. Since genetic testing is expensive and not readily available, it would seem reasonable for all people trying to lower their homocysteine levels to include riboflavin in their regimen of B vitamin supplementation.

    2 Stars
    Parkinson's Disease
    30 mg three times a day
    In one study, people with Parkinson's disease who had vitamin B2 (riboflavin) deficiency and supplemented with riboflavin experienced improved motor capacity.

    In a preliminary study of 31 Brazilian individuals with Parkinson's disease, all had laboratory evidence of vitamin B2 (riboflavin) deficiency. Nineteen of these individuals received 30 mg of supplemental riboflavin three times a day for six months. After three months, all participants treated with riboflavin demonstrated an improvement in motor capacity, and this improvement was either maintained or greater at six months. The participants in this study also eliminated red meat from their diet, but it is not clear whether that dietary change played any role in the observed improvement.

    1 Star
    Preeclampsia
    Refer to label instructions
    Women who are deficient in vitamin B2 (riboflavin) are more likely to develop preeclampsia than women with normal levels. Supplementation may correct a deficiency.

    Women who are deficient in vitamin B2 (riboflavin) are more likely to develop preeclampsia than women with normal vitamin B2 levels. These results were observed in a developing country, where vitamin B2 deficiencies are more common than in the United States. Nevertheless, insufficient vitamin B2 may contribute to the abnormalities underlying the disease process.

    How It Works

    How to Use It

    The ideal level of intake is not known. The amounts found in many multivitamin supplements (20-25 mg) are more than adequate for most people.

    Where to Find It

    Dairy products, eggs, and meat contain significant amounts of vitamin B2. Leafy green vegetables, whole grains, and enriched grains contain some vitamin B2.

    Possible Deficiencies

    Vitamin B2 deficiency can occur in alcoholics . Also, a deficiency may be more likely in people with cataracts 1 , 2 or sickle cell anemia .3 In developing countries, vitamin B2 deficiency has been found to be a risk factor for the development of preeclampsia in pregnant women.4 People with chronic fatigue syndrome may be deficient in vitamin B2.5

    Best Form to Take

    Riboflavin is the most commonly used supplement form of vitamin B2 and most clinical trials have used that form. The biologically active form of vitamin B2-riboflavin 5'-phosphate-is also commercially available, although most of it is converted into riboflavin in the intestine before being absorbed.6

    Interactions

    Interactions with Supplements, Foods, & Other Compounds

    Vitamin B2 works with vitamin B1 , vitamin B3 , and vitamin B6 . For that reason, vitamin B2 is often taken as part of a B-complex supplement.

    Interactions with Medicines

    Certain medicines interact with this supplement.

    Types of interactions: Beneficial Adverse Check

    Replenish Depleted Nutrients

    • Amikacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Aminosalicylic Acid

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Amoxicillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Amoxicillin-Potassium Clavulanate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ampicillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ampicillin Sodium

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ampicillin with Sulbactam

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Azithromycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Azithromycin Hydrogen Citrate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Aztreonam

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Aztreonam in Dextrose(IsoOsm)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Bacampicillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Bacitracin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Capreomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefaclor

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefadroxil

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefamandole

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefazolin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefazolin in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefazolin in Dextrose (Iso-os)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefazolin in Normal Saline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefazolin Sodium-Sterile Water

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefdinir

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefditoren Pivoxil

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefepime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefixime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefonicid

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefoperazone

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefotaxime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefotaxime in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefotetan

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefotetan in Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefotetan in Dextrose, Iso-osm

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefoxitin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefoxitin in 2.2% Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefoxitin in 3.9% Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefoxitin in Dextrose, Iso-osm

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefpodoxime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefprozil

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftaroline Fosamil

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftazidime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftazidime-Dextrose (Iso-osm)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftibuten

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftizoxime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftriaxone

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ceftriaxone-Dextrose (Iso-osm)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cefuroxime

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cephalexin HCl

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cephalothin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cephapirin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Chloramphenicol

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ciprofloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ciprofloxacin in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Clarithromycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Clindamycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Clindamycin HCl

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Clindamycin in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Clindamycin Palmitate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cloxacillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Colistimethate Sodium

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Cycloserine

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Dapsone

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Daptomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Demeclocycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Desogestrel-Ethinyl Estradiol

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A .Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Dicloxacillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Dirithromycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Doripenem

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Doxorubicin
      Animal studies suggest that doxorubicin interferes with the body's utilization of riboflavin (vitamin B2). In rats, supplementation with riboflavin prevented the development of cardiac abnormalities resulting from treatment with doxorubicin.
    • Doxycycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ertapenem

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Erythromycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Erythromycin Ethylsuccinate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Erythromycin Lactobionate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Erythromycin Stearate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Erythromycin-Sulfisoxazole

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Estradiol-Drospirenone

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Ethambutol

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ethinyl Estradiol and Norethindrone

      A review of literature suggests that women who use OCs may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A .OCs may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Ethinyl Estradiol and Norgestimate

      A review of literature suggests that women who use OCs may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. OC use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . OCs may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Ethinyl Estradiol and Norgestrel

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Ethionamide

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Fidaxomicin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gatifloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gatifloxacin in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gemifloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gentamicin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gentamicin (Pediatric)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gentamicin in Normal Saline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gentamicin in Saline (Iso-osm)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Gentamicin Sulfate (Ped-PF)

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Imipenem-Cilastatin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Isoniazid

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Isoniazid-Rifampin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Isoniazid-Rifamp-Pyrazinamide

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Levofloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Levofloxacin in D5W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Levonorgestrel-Ethinyl Estrad

      A review of literature suggests that women who use oral contraceptivess may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptives use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptivess may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Lincomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Linezolid

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Meropenem

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Mestranol and Norethindrone

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Mezlocillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Minocycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Moxifloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Moxifloxacin in Saline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Nafcillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Nafcillin in D2.4W

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Neomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Netilmicin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Norethindrone (Contraceptive)

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Norethindrone Ac-Eth Estradiol

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Norfloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Norgestimate-Ethinyl Estradiol

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A .Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Norgestrel

      A review of literature suggests that women who use oral contraceptives may experience decreased vitamin B1 , B2, B3 , B12 , C , and zinc levels. Oral contraceptive use has been associated with increased absorption of calcium and copper and with increased blood levels of copper and vitamin A . Oral contraceptives may interfere with manganese absorption. The clinical importance of these actions remains unclear.

    • Ofloxacin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Oxacillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Oxacillin in Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Oxytetracycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G Benzathine

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G Benzathine & Proc

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G Pot in Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G Potassium

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin G Procaine

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Penicillin V

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Piperacillin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Piperacillin-Tazobactam

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Piperacillin-Tazobactam-Dextrs

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Pyrazinamide

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Quinupristin-Dalfopristin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Rifabutin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Rifampin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Rifapentine

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Rifaximin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Streptomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Sulfadiazine

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Sulfamethoxazole

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Sulfisoxazole

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Tedizolid

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Telavancin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Telithromycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Tetracycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Thalidomide

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Ticarcillin-Clavulanate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Tigecycline

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Tobramycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Tobramycin Sulfate

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Trimethoprim

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Trimethoprim/ Sulfamethoxazole

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Troleandomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Vancomycin

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    • Vancomycin in Dextrose

      Tetracycline can interfere with the activity of folic acid , potassium , and vitamin B2, vitamin B6 , vitamin B12 , vitamin C , and vitamin K . This is generally not a problem when taking tetracycline for two weeks or less. People taking tetracycline for longer than two weeks should ask their doctor about vitamin and mineral supplementation. Taking 500 mg vitamin C simultaneously with tetracycline was shown to increase blood levels of tetracycline in one study. The importance of this interaction is unknown.

    Reduce Side Effects

    • AZT

      Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    • Didanosine

      Persons with AIDS have developed lactic acidosis and fatty liver while taking didanosine and other drugs in its class. Didanosine can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    • Doxorubicin

      Animal research suggests doxorubicin may deplete riboflavin and that riboflavin deficiency promotes doxorubicin toxicity.

    • Emtricitabine

      Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    • Lamivudine

      Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    • Stavudine

      Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    • Zidovudine

      Persons with AIDS have developed lactic acidosis and fatty liver while taking AZT and other drugs in its class. AZT can inhibit crucial DNA-related riboflavin activity, which may be normalized by riboflavin supplementation. A 46-year-old woman with AIDS and lactic acidosis received a single dose of 50 mg of riboflavin, after which her laboratory tests returned to normal and her lactic acidosis was completely resolved. More research is needed to confirm the value of riboflavin for preventing and treating this side effect.

    Support Medicine

    • Amitriptyline

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Clomipramine

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Desipramine

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

      Combination of 6 grams per day L-tryptophan and 1,500 mg per day niacinamide (a form of vitamin B3) with imipramine has shown to be more effective than imipramine alone for people with bipolar disorder . These levels did not improve the effects of imipramine in people with depression . Lower amounts (4 grams per day of L-tryptophan and 1,000 mg per day of niacinamide) did show some tendency to enhance the effect of imipramine.

      The importance of the amount of L-tryptophan was confirmed in other studies, suggesting that if too much L-tryptophan (6 grams per day) is used, it is not beneficial, while levels around 4 grams per day may make tricyclic antidepressants work better.

    • Doxepin

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Imipramine

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Nortriptyline

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Protriptyline

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    • Trimipramine

      Giving 10 mg per day each of vitamins B1 , B2, and B6 to elderly, depressed persons already on tricyclic antidepressants improved their depression and ability to think more than placebo did. The subjects in this study were institutionalized, so it is unclear if these results apply to persons living at home.

    Reduces Effectiveness

    • none

    Potential Negative Interaction

    • none

    Explanation Required

    • none

    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

    Side Effects

    Side Effects

    At supplemental and dietary levels, vitamin B2 is nontoxic.

    References

    1. Bhat KS. Nutritional status of thiamine, riboflavin and pyridoxine in cataract patients. Nutr Rep Internat 1987;36:685-92.

    2. Prchal JT, Conrad ME, Skalka HW. Association of presenile cataracts with heterozygosity for galactosaemic states and with riboflavin deficiency. Lancet 1978; 1:12-3.

    3. Varma RN, Mankad VN, Phelps DD, et al. Depressed erythrocyte glutathione reductase activity in sickle cell disease. Am J Clin Nutr 1983;38:884-7.

    4. Wacker J, Fruhauf J, Schulz M, et al. Riboflavin deficiency and preeclampsia. Obstet Gynecol 2000;96:38-44.

    5. Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med 1999;92:183-5.

    6. Gaby, AR. Nutritional Medicine. Concord, NH: Friz Perlberg Publishing, 2011.

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