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    Amylase Inhibitors

    Amylase Inhibitors

    Uses

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    3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit.

    2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

    1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

    This supplement has been used in connection with the following health conditions:

    Used for Why
    1 Star
    Obesity
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    Amylase inhibitors are also known as starch blockers because they contain substances that prevent dietary starches from being absorbed by the body. Starches are complex carbohydrates that cannot be absorbed unless they are first broken down by the digestive enzyme amylase and other, secondary, enzymes.10 , 11 When starch blockers were first developed years ago, they were found not to be potent enough to prevent the absorption of a significant amount of carbohydrate.12 , 13 , 14 , 15 Recently, highly concentrated starch blockers have been shown to be more effective,16 , 17 , 18 but no published human studies exist investigating their usefulness for weight loss.
    1 Star
    Type 1 Diabetes
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    Starch blockers are substances that inhibit amylase, the digestive enzyme required to break down dietary starches for normal absorption. Controlled research has demonstrated that concentrated starch blocker extracts, when given with a starchy meal, can reduce the usual rise in blood sugar levels of both healthy people and diabetics.19 , 20 , 21 , 22 , 23 While this effect could be helpful in controlling diabetes, no research has investigated the long-term effects of taking starch blockers for this condition.
    1 Star
    Type 2 Diabetes
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    Starch blockers are substances that inhibit amylase, the digestive enzyme required to break down dietary starches for normal absorption. Controlled research has demonstrated that concentrated starch blocker extracts, when given with a starchy meal, can reduce the usual rise in blood sugar levels of both healthy people and diabetics.24 , 25 , 26 , 27 , 28 While this effect could be helpful in controlling diabetes, no research has investigated the long-term effects of taking starch blockers for this condition.

    How It Works

    How to Use It

    Depending on the potency of the amylase inhibitors , typical intake is 1,500 to 6,000 mg before meals.

    Where to Find It

    Amylase inhibitors can be extracted from several types of plants, especially those in the legume family. Currently available Amylase inhibitors are extracted from either white kidney bean or wheat.

    Possible Deficiencies

    Amylase inhibitors are not essential nutrients and are not normally produced in the body, so no deficiency is possible.

    Interactions

    Interactions with Supplements, Foods, & Other Compounds

    Diabetics taking medications to lower their blood sugar should not take amylase inhibitors without first consulting a doctor.

    Interactions with Medicines

    As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
    The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers' package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

    Side Effects

    Side Effects

    High amounts of amylase inhibitors may cause diarrhea due to the effects of undigested starch in the colon.29 , 30

    References

    1. Marshall JJ, Lauda CM. Purification and properties of phaseolamin, an inhibitor of alpha-amylase, from the kidney bean, Phaseolus vulgaris. J Biol Chem 1975;250:8030-7.

    2. Choudhury A, Maeda K, Murayama R, DiMagno EP. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111:1313-20.

    3. Bo-Linn GW, Santa Ana CA, Morawski SG, Fordtran JS. Starch blockers-their effect on calorie absorption from a high-starch meal. N Engl J Med 1982;307:1413-6.

    4. Hollenbeck CB, Coulston AM, Quan R, et al. Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 1983;38:498-503.

    5. Garrow JS, Scott PF, Heels S, et al. A study of 'starch blockers' in man using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr 1983;37:301-5.

    6. Carlson GL, Li BU, Bass P, Olsen WA. A bean alpha-amylase inhibitor formulation (starch blocker) is ineffective in man. Science 1983;219:393-5.

    7. Brugge WR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor. Am J Gastroenterol 1987;82:718-22.

    8. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

    9. Layer P, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase in humans. Gastroenterology 1985;88:1895-902.

    10. Marshall JJ, Lauda CM. Purification and properties of phaseolamin, an inhibitor of alpha-amylase, from the kidney bean, Phaseolus vulgaris. J Biol Chem 1975;250:8030-7.

    11. Choudhury A, Maeda K, Murayama R, DiMagno EP. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 1996;111:1313-20.

    12. Bo-Linn GW, Santa Ana CA, Morawski SG, Fordtran JS. Starchblockers-their effect on calorie absorption from a high-starch meal. N Engl JMed 1982;307:1413-6.

    13. Hollenbeck CB, Coulston AM, Quan R, et al.Effects of a commercial starch blocker preparation on carbohydrate digestion and absorption: in vivo and in vitro studies. Am J Clin Nutr 1983;38:498-503.

    14. GarrowJS, Scott PF, Heels S, et al. A study of starch blockers in man using 13C-enriched starch as a tracer. Hum Nutr Clin Nutr 1983;37:301-5.

    15. CarlsonGL, Li BU, Bass P, Olsen WA. A bean alpha-amylase inhibitor formulation (starchblocker) is ineffective in man. Science 1983;219:393-5.

    16. BruggeWR, Rosenfeld MS. Impairment of starch absorption by a potent amylase inhibitor.Am J Gastroenterol 1987;82:718-22.

    17. Boivin M, Zinsmeister AR, Go VL,DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

    18. LayerP, Carlson GL, DiMagno EP. Partially purified white bean amylase inhibitor reduces starch digestion in vitro and inactivates intraduodenal amylase inhumans. Gastroenterology 1985;88:1895-902.

    19. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

    20. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology1988;94:387-94.

    21. Lankisch M, Layer P, Rizza RA, DiMagno EP. Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans. Pancreas1998;17:176-81.

    22. Holt PR, Thea D, Yang MY, Kotler DP. Intestinal and metabolic responses to an alpha-glucosidase inhibitor in normal volunteers. Metabolism1988;37:1163-70.

    23. Layer P, Rizza RA, Zinsmeister AR, et al. Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus. Mayo Clin Proc 1986;61:442-7.

    24. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

    25. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94:387-94.

    26. Lankisch M, Layer P, Rizza RA, DiMagno EP. Acute postprandial gastrointestinal and metabolic effects of wheat amylase inhibitor (WAI) in normal, obese, and diabetic humans. Pancreas 1998;17:176-81.

    27. Holt PR, Thea D, Yang MY, Kotler DP. Intestinal and metabolic responses to an alpha-glucosidase inhibitor in normal volunteers. Metabolism 1988;37:1163-70.

    28. Layer P, Rizza RA, Zinsmeister AR, et al. Effect of a purified amylase inhibitor on carbohydrate tolerance in normal subjects and patients with diabetes mellitus. Mayo Clin Proc 1986;61:442-7.

    29. Boivin M, Zinsmeister AR, Go VL, DiMagno EP. Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clin Proc 1987;62:249-55.

    30. Boivin M, Flourie B, Rizza RA, et al. Gastrointestinal and metabolic effects of amylase inhibition in diabetics. Gastroenterology 1988;94:387-94.

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