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    Mixed Connective Tissue Disease (MCTD)

    Mixed Connective Tissue Disease (MCTD)

    National Organization for Rare Disorders, Inc.

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    It is possible that the main title of the report Mixed Connective Tissue Disease (MCTD) is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


    • Connective Tissue Disease
    • MCTD

    Disorder Subdivisions

    • None

    General Discussion

    Mixed connective tissue disease (MTCD) is a rare connective tissue disorder. MCTD is used to describe what may be an overlapping group of connective tissue disorders that cannot be diagnosed in more specific terms. These disorders include systemic lupus erythematosus, polymyositis, and scleroderma. Individuals with MCTD have symptoms of each of these disorders including arthritic, cardiac, pulmonary and skin manifestations; kidney disease; muscle weakness, and dysfunction of the esophagus. The exact cause of mixed connective tissue disease is unknown.


    Scleroderma Research Foundation
    220 Montgomery Street
    Suite 1411
    San Francisco, CA 94104
    Tel: (415)834-9444
    Fax: (415)834-9177
    Tel: (800)441-2873
    Email: srfcure@sclerodermaresearch.org
    Internet: http://www.srfcure.org/home

    Scleroderma Foundation
    300 Rosewood Drive, Suite 105
    Danvers, MA 01923
    Tel: (978)463-5843
    Fax: (978)463-5809
    Tel: (800)722-4673
    Email: sfinfo@scleroderma.org
    Internet: http://www.scleroderma.org

    American Autoimmune Related Diseases Association, Inc.
    22100 Gratiot Ave.
    Eastpointe, MI 48021
    Tel: (586)776-3900
    Fax: (586)776-3903
    Tel: (800)598-4668
    Email: aarda@aarda.org
    Internet: http://www.aarda.org/

    The Marfan Foundation
    22 Manhasset Avenue
    Port Washington, NY 11050
    Tel: (516)883-8712
    Fax: (516)883-8040
    Tel: (800)862-7326
    Email: staff@marfan.org
    Internet: http://www.marfan.org

    Lupus Foundation of America, Inc.
    2000 L Street NW
    Suite 710
    Washington, DC 20036
    Tel: (202)349-1155
    Fax: (202)349-1156
    Tel: (800)558-0121
    Email: info@lupus.org
    Internet: http://www.lupus.org

    Sjogren's Syndrome Foundation, Inc.
    6707 Democracy Blvd
    Suite 325
    Bethesda, MD 20817
    Tel: (301)530-4420
    Fax: (301)530-4415
    Tel: (800)475-6473
    Email: tms@sjogrens.org
    Internet: http://www.sjogrens.org

    Arthritis Foundation
    1330 West Peachtree Street, Suite 100
    Atlanta, GA 30309
    Tel: (404)872-7100
    Tel: (800)283-7800
    Email: arthritisfoundation@arthritis.org
    Internet: http://www.arthritis.org

    NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
    Information Clearinghouse
    One AMS Circle
    Bethesda, MD 20892-3675
    Tel: (301)495-4484
    Fax: (301)718-6366
    Tel: (877)226-4267
    TDD: (301)565-2966
    Email: NIAMSinfo@mail.nih.gov
    Internet: http://www.niams.nih.gov/

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Autoimmune Information Network, Inc.
    PO Box 4121
    Brick, NJ 08723
    Fax: (732)543-7285
    Email: autoimmunehelp@aol.com

    International Scleroderma Network
    7455 France Ave So #266
    Edina, MN 55435-4702
    Tel: (952)583-5735
    Tel: (800)564-7099
    Email: isn@sclero.org
    Internet: http://www.sclero.org

    European Society for Immunodeficiencies
    1-3 rue de Chantepoulet
    Geneva, CH 1211
    Tel: 410229080484
    Fax: 41229069140
    Email: esid@kenes.com
    Internet: http://www.esid.org

    AutoImmunity Community
    Email: moderator@autoimmunitycommunity.org
    Internet: http://www.autoimmunitycommunity.org

    Cogan's Contact Network
    PO Box 145
    Freehold, NJ 07728-0145
    Tel: (732)409-1031
    Internet: http://www.coganssyndrome.info/

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated:  10/12/2007
    Copyright  1987, 1989, 1996, 2001, 2007 National Organization for Rare Disorders, Inc.

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