Display Mode:

    Main content

    Health Information

    Endomyocardial Fibrosis

    Endomyocardial Fibrosis

    National Organization for Rare Disorders, Inc.

    Skip to the navigation

    It is possible that the main title of the report Endomyocardial Fibrosis is not the name you expected.

    Disorder Subdivisions

    • None

    General Discussion

    Endomyocardial fibrosis (EMF) is a progressive disease of unknown origin (idiopathic) that may seriously affect the heart. Its most obvious feature is a gross change in the makeup of the lining of the heart cavities (the endocardium) of one or both of the lower chambers of the heart (the ventricles) leading to the replacement of normal cells with fibrous tissue (fibrosis). This process is progressive and leads to the narrowing (constriction) of the right or left ventricular cavities. It may involve the valves between the chambers of the heart as well as the tendon-like cords that fix the valves to the ventricles (chordae tendineae).

    Loeffler's disease is a disease of the heart much like endomyocardial fibrosis. Some clinicians regard it as an early stage of EMF, although this idea remains controversial. Loeffler's disease is a rare disorder of unknown origin, characterized by abnormal increases in the number of particular white blood cells (eosinophilia), and like EMF, gross fibrosis of the endocardium, and inflammation of small blood vessels (arteritis).

    Supporting Organizations

    American Heart Association

    7272 Greenville Avenue
    Dallas, TX 75231
    Tel: (214)784-7212
    Fax: (214)784-1307
    Tel: (800)242-8721
    Email: Review.personal.info@heart.org
    Website: http://www.heart.org

    Centers for Disease Control and Prevention

    1600 Clifton Road NE
    Atlanta, GA 30333
    Tel: (404)639-3534
    Tel: (800)232-4636
    Email: cdcinfo@cdc.gov
    Website: http://www.cdc.gov/

    Genetic and Rare Diseases (GARD) Information Center

    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    Website: http://rarediseases.info.nih.gov/GARD/

    Myocarditis Foundation

    100 W Main St
    Utica, MN 55979
    Tel: (732)295-3700
    Fax: (732)295-3701
    Tel: (866)846-1600
    Email: candace@myocarditisfoundation.org
    Website: http://www.myocarditisfoundation.org/

    For a Complete Report

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    Last Updated:  4/24/2015
    Copyright  2015 National Organization for Rare Disorders, Inc.

    This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. Learn how we develop our content.

    Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.