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Content

Interferon beta-1a in children with multiple sclerosis is well tolerated.

Description

Waubant E, Hietpas J, Stewart T, Dyme Z, Herbert J, Lacy J, Miller C, Rensel M, Schwid S, Goodkin D., Neuropediatrics. 32(4):211-3., 2001 Aug 01

Investigators

Joseph R. Lacy, M.D.

Abstract

BACKGROUND: Multiple sclerosis is a chronic demyelinating disease rare in children. Currently marketed disease modifying therapies are limited to adults.

OBJECTIVE: To determine the tolerability of interferon beta-1a (IFNB-1a) 30 mcg injected intramuscularly once a week in children with clinically definite relapsing-remitting multiple sclerosis (RRMS).

DESIGN/METHODS: A standardized questionnaire was sent to neurologists in the United States to determine the tolerability of IFNB-1a in patients younger than 16 years.

RESULTS: Tolerability data were available for 9 of 33 children who were reported to initiate IFNB-1a. Mean age on initiating treatment was 12.7 years (range 8 - 15) and mean duration of therapy was 17 months (range 5 - 36). No patient discontinued therapy due to an adverse event.

CONCLUSIONS: Preliminary data indicate that weekly intramuscular injections of IFNB-1a are well tolerated.

Pubmed Abstract

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Associated Topics

  • Child and Adolescent Health
  • Disease Management
  • Neurological Disorders

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