--- title: "Is ALS Hereditary? | Sutter Health" description: "Is ALS hereditary?" url: "/ask-an-expert/answers/is-als-hereditary-2013067855" --- 1. Home / 2. Is ALS Hereditary? # Is ALS Hereditary? * * * Medically reviewed by - Andrew Muller, MPH, MHA, MPH, MHA ## Question Is ALS hereditary? ## Answer Yes, amyotrophic lateral sclerosis (ALS) can be hereditary. About 10% of people diagnosed with ALS have a form called familial ALS (FALS), which is passed down through inherited gene mutations in families. The remaining 90% of cases are known as sporadic ALS, which occur without a known family history. Thanks to ongoing research, scientists have identified several gene mutations linked to ALS. The most common inherited form is tied to a mutation in the C9orf72 gene. Other genes linked to ALS include SOD1, FUS and TARDBP. The way ALS is inherited depends on the gene involved: - Autosomal dominant inheritance means only one parent needs to carry the mutation for it to be passed on. - Autosomal recessive inheritance means both parents must carry the mutation. - X-linked inheritance is connected to the X chromosome and may affect males more significantly. If ALS runs in your family, it’s natural to have questions about what that means for your own health. This is where genetic testing and counseling can be incredibly helpful. A genetic specialist can talk with you about your personal risk, explain what your results might mean for both you and your loved ones, and help guide important decisions about your future care and planning. At Sutter’s Forbes Norris MDA/ALS Research & Treatment Center , we offer advanced genetic services and access to groundbreaking clinical trials. Our goal is to provide personalized care today while working toward a cure for tomorrow. ## Support From Diagnosis to Daily Life A diagnosis of ALS changes everything, but you don’t have to face it alone. Our nationally recognized ALS clinicians offer guidance and care. Request a Referral ## Related questions View all questions - Health Q&A ### What Is ALS? What is ALS? - Health Q&A ### What Are Common Signs of Autism? What are common signs of autism in kids, teens and adults? - Health Q&A ### What Is Autism? What is autism?  View all questions ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Is ALS Hereditary?"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#medicalwebpage","url":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855","name":"Is ALS Hereditary?","description":"Yes, amyotrophic lateral sclerosis (ALS) can be hereditary. About 10% of people diagnosed with ALS have a form called familial ALS (FALS), which is passed down through inherited gene mutations in families.","inLanguage":"en-US","medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"isPartOf":{"@id":"https://www.sutterhealth.org/ask-an-expert/answers"},"breadcrumb":{"@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#breadcrumblist"},"mainEntity":{"@type":"Question","@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#question","name":"Is ALS Hereditary?","text":"Is ALS hereditary?","acceptedAnswer":{"@type":"Answer","@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#answer","text":"Yes, amyotrophic lateral sclerosis (ALS) can be hereditary. About 10% of people diagnosed with ALS have a form called familial ALS (FALS), which is passed down through inherited gene mutations in families. The remaining 90% of cases are known as sporadic ALS, which occur without a known family history. Thanks to ongoing research, scientists have identified several gene mutations linked to ALS. The most common inherited form is tied to a mutation in the C9orf72 gene. Other genes linked to ALS include SOD1, FUS and TARDBP. The way ALS is inherited depends on the gene involved: Autosomal dominant inheritance means only one parent needs to carry the mutation for it to be passed on. Autosomal recessive inheritance means both parents must carry the mutation. X-linked inheritance is connected to the X chromosome and may affect males more significantly. If ALS runs in your family, it’s natural to have questions about what that means for your own health. This is where genetic testing and counseling can be incredibly helpful. A genetic specialist can talk with you about your personal risk, explain what your results might mean for both you and your loved ones, and help guide important decisions about your future care and planning. At Sutter’s Forbes Norris MDA/ALS Research & Treatment Center, we offer advanced genetic services and access to groundbreaking clinical trials. Our goal is to provide personalized care today while working toward a cure for tomorrow.","url":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855","author":{"@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#expert"}}},"publisher":{"@id":"https://www.sutterhealth.org/#medicalorganization"},"reviewedBy":{"@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#expert"}} ``` ```json {"@context":"https://schema.org","@type":"Person","@id":"https://www.sutterhealth.org/ask-an-expert/answers/is-als-hereditary-2013067855#expert","name":"Andrew Muller, MPH, MHA","honorificSuffix":["MPH","MHA"]} ```