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A phase III multicenter, randomized, double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of fenebrutinib compared with ocrelizumab in adult patients with PPMS

Study Information

Status: Active, Recruiting

Study Details

View study details on clinicaltrials.gov.

Locations

Palo Alto/Santa Cruz

Clinical Trial FAQs

Information for patients and study volunteers, including frequently asked questions.

Contact Us to Enroll

Description

A Multiple Sclerosis study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomized 1:1 to either daily oral fenebrutinib (or placebo) or intravenous (IV) ocrelizumab (or placebo) in a blinded fashion. Approximately 946 participants will be enrolled and will be recruited globally.

Principal Investigator

Ariele L Greenfield, M.D., Director of PAMF Multiple Sclerosis Center

Co-Investigator(s)

Minal Bhanushali, MD, PAMFRI Medical Director, Christine Hessler, MD, David Gershfield, MD 

Funder

F. Hoffman-La Roche Ltd

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