Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial.

Gladding P1, Panattoni L, Webster M, Cho L, Ellis S., JACC Cardiovasc Interv. 3(10):995-1000. doi: 10.1016/j.jcin.2010.08.012., 2010 Oct 01

Abstract

Clopidogrel pharmacogenomics has received significant attention since a black box warning was announced by the Food and Drug Administration in March 2010.

This has left clinicians in a difficult situation where many questions remain unanswered.

In this brief viewpoint article, we ask some pointed questions of our own and outline the pathway that needs to be taken for clinical translation to occur.

Pubmed Abstract

Pubmed AbstractOpens New Window

Associated Topics

Related Publications

Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach.

Yan XS, Barnholtz-Sloan J, Chu X, Li L, Colonie R, Webster J, Smelser D, Patel N, Prichard J, Stark A.
Springerplus. 2:638. doi: 10.1186/2193-1801-2-638. eCollection 2013.
2013 Nov 27

Diverse transcriptional programs associated with environmental stress and hormones in the Arabidopsis receptor-like kinase gene family.

Chae L, Sudat S, Dudoit S, Zhu T, Luan S.
Mol Plant. 2(1):84-107. doi: 10.1093/mp/ssn083.
2009 Jan 01

Does the diagnosis of breast or ovarian cancer trigger referral to genetic counseling?

Powell CB, Littell R, Hoodfar E, Sinclair F, Pressman A.
Int J Gynecol Cancer. 23(3):431-6. doi: 10.1097/IGC.0b013e318280f2b4.
2013 Mar 01

The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine.

Rahm AK, Ladd I, Burnett-Hartman AN, Epstein MM, Lowery JT, Lu CY, Pawloski PA, Sharaf RN, Liang SY, Hunter JE.
EGEMS (Wash DC). 7(1):16. doi: 10.5334/egems.283.
2019 Apr 12

Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts.

Rahm AK, Cragun D, Hunter JE, Epstein MM, Lowery J, Lu CY, Pawloski PA, Sharaf RN, Liang SY, Burnett-Hartman AN, Gudgeon JM, Hao J, Snyder S, Gogoi R, Ladd I, Williams MS.
BMC Health Serv Res. 18(1):824. doi: 10.1186/s12913-018-3636-2.
2018 Oct 30

Clopidogrel pharmacogenomics: next steps: a clinical algorithm, gene-gene interactions, and an elusive outcomes trial.

Abstract

Pubmed Abstract

Associated Topics

Related Publications

Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach.

Diverse transcriptional programs associated with environmental stress and hormones in the Arabidopsis receptor-like kinase gene family.

Does the diagnosis of breast or ovarian cancer trigger referral to genetic counseling?

The Healthcare Systems Research Network (HCSRN) as an environment for dissemination and implementation research: a case study of developing a multi-site research study in precision medicine.

Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts.

About Sutter

Find Care

Featured Services

Patient Resources

Our Team