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Testosterone Loss in Men

Women aren’t the only ones who suffer the effects of changing hormones. Men experience hormone decreases in middle age, too. Learn what to do about it.

Phillip L. Ross, M.D., FRCSC

Contributor

Phillip L. Ross, M.D., FRCSC

Sutter East Bay Medical Foundation

Sutter Delta Medical Center

Ronald D  Cotterel, M.D., M.S.

Contributor

Ronald D Cotterel, M.D., M.S.

Sutter Medical Foundation

Sutter Davis Hospital

Everyone has heard of menopause. Fewer know about the decline in male hormones in middle age called andropause.

Andropause is not really a pause where the body stops its normal cycling of hormones, as happens in menopause. Rather, it is a very gradual and normal decline in the production of male hormones as a man ages, explains Phillip Ross, M.D., a urologist with Sutter East Bay Medical Foundation.

This loss of hormones, in particular testosterone, is behind many of the physical symptoms you may associate with middle age in men, such as a tendency to put on weight, feeling more tired and experiencing a decline in sex drive.

“While the normal midlife passage of menopause for women is clearly defined, what happens to men is less consistent, clear or even talked about,” Dr. Ross explains. “There is a measurable decline in testosterone – and other male hormones – that actually begins as early as the 30s. Production of male hormones peaks for men in their late teens to early 20s. Then it begins a slow, slight decline.”

Because the decline in male hormones is gradual, you may not notice a change for many years. However, once you enter your 40s or 50s, the signs of lower hormone levels may become clearer. By the time men reach their 60s, a quarter may show laboratory evidence of low testosterone – and by age 80, half will.

Although andropause usually does not require treatment, if male hormone levels get very low, it can begin to impact a man’s quality of life and health. Ron Cotterel, M.D., a family medicine physician with Sutter Medical Foundation, has a special interest in complementary medicine and works with men to manage physical concerns of declining hormone levels in ways that work best for them.

“Although all men will show some decline in testosterone, many men will retain functional testosterone levels normal for their age throughout life,” Dr. Cotterel says. “And the way in which the testosterone change affects men varies from person to person.”

Signs of Testosterone Loss

The symptoms of low testosterone are ones that every man has experienced at one point or another, which makes it tricky to tell if you are experiencing andropause, Dr. Ross explains. Signs to look for include:

  • Fatigue/lack of motivation
  • Sleep disturbances
  • Slow thinking or difficulty concentrating
  • Increased body fat
  • Decreased muscle mass
  • Hair and skin changes
  • Change in mood
  • Decreased sexual desire or function

Treating Low Testosterone

If you suspect that you may have low testosterone, seek the advice of your primary care doctor. Usually, the classic advice for good health – eat smaller, healthier meals and exercise more – is all that is needed to help retain health and vigor in midlife. However, for men who are suffering from a measurable drop in testosterone, that advice alone may not work.

 Older man doing push ups outside on the grass

“A man with a measurable drop in testosterone may just not have any ‘get up and go,’ ” Dr. Ross says. “It is harder for him to exercise, or he may make the effort to exercise and eat better, but still find that his symptoms persist.”

Dr. Ross and Dr. Cotterel both caution that taking additional testosterone, above normal levels, can have negative effects. In fact, for young men, it can be devastating – causing the testicles to stop their own natural production of the vital hormone. This can impact fertility and potentially necessitate lifelong hormone supplementation. Studies have also linked testosterone replacement therapy with an increased risk of cardiovascular disease, blood clots and stroke.

“Despite all of the radio and television ads about ‘low T,’ routine testing of testosterone is only recommended in certain situations,” Dr. Cotterel says. Testosterone level testing is indicated if there is evidence of:

  • Incomplete or delayed sexual development
  • Reduced sexual desire (libido) and activity
  • Decreased spontaneous erections
  • Breast discomfort (gynecomastia)
  • Loss of axillary and pubic body hair, reduced shaving
  • Very small (especially less than 5 ml) or shrinking testes
  • Inability to father children, low or zero sperm count
  • Height loss, fragility fracture, low bone mineral density
  • Hot flashes, sweats

Work with your doctor to determine if your symptoms truly are related to a low testosterone levels and if the benefits of treatment will outweigh any risks.

Testosterone Replacement Options

If hormone replacement is right for you, there are five main options:

Intramuscular Injections

Usually given every two to four weeks, intramuscular injections work well and are cost effective. The downsides: These injections create a fluctuation in hormone levels, which peak just after the shot and then decline. They also require regular visits to a medical practitioner.

Transdermal Applications

Here testosterone is slowly absorbed from a patch on the skin. This steady constant dose more closely mimics natural testosterone delivery. The downside is that it may not provide as large a dose of testosterone as some men might need. In addition, the patch can irritate some men’s skin.

Buccal (By Mouth) Delivery

Discreet and convenient small strips that dissolve in the mouth are taken twice a day. These provide good delivery of testosterone at the right dose. However, the strips are more costly than other options and remembering to take them twice a day can be cumbersome. In addition, some men develop mouth irritation from the strips.

Transdermal Gels

With transdermal gels, testosterone is conveniently and discreetly absorbed through the skin. Gels provide good delivery of the right dose, but they can rub of on other people who may touch you. They must always be applied under clothing and the area with the gel on it should never be touched by women or children. After applying the gel, wash hands carefully and avoid touching people or pets immediately after having had the gel on your hands.

Nasal Spray

A nasal spray is used three times a day in each nostril. It is discreet and convenient like a gel without the risk that it could rub off on others. A disadvantage is that it can cause a runny nose, sore throat and nasal infection in some men, particularly those with allergies and other nasal or sinus problems.

Note that none of these options include a pill – blue or not. Testosterone therapy is not the same as medication for erectile dysfunction. You can learn more about erectile dysfunction here.

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