The ENGAGE study: Integrating neuroimaging, virtual reality and smartphone sensing to understand self-regulation for managing depression and obesity in a precision medicine model.

Williams LM, Pines A, Goldstein-Piekarski AN, Rosas LG, Kullar M, Sacchet MD, Gevaert O, Bailenson J, Lavori PW, Dagum P, Wandell B, Correa C, Greenleaf W, Suppes T, Perry LM, Smyth JM, Lewis MA, Venditti EM, Snowden M, Simmons JM, Ma J., Behav Res Ther. pii: S0005-7967(17)30202-4. doi: 10.1016/j.brat.2017.09.012. [Epub ahead of print], 2017 Oct 07

Abstract

Precision medicine models for personalizing achieving sustained behavior change are largely outside of current clinical practice. Yet, changing self-regulatory behaviors is fundamental to the self-management of complex lifestyle-related chronic conditions such as depression and obesity - two top contributors to the global burden of disease and disability. To optimize treatments and address these burdens, behavior change and self-regulation must be better understood in relation to their neurobiological underpinnings.

Here, we present the conceptual framework and protocol for a novel study, "Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomes (ENGAGE)". The ENGAGE study integrates neuroscience with behavioral science to better understand the self-regulation related mechanisms of behavior change for improving mood and weight outcomes among adults with comorbid depression and obesity.

We collect assays of three self-regulation targets (emotion, cognition, and self-reflection) in multiple settings: neuroimaging and behavioral lab-based measures, virtual reality, and passive smartphone sampling.

By connecting human neuroscience and behavioral science in this manner within the ENGAGE study, we develop a prototype for elucidating the underlying self-regulation mechanisms of behavior change outcomes and their application in optimizing intervention strategies for multiple chronic diseases.

Pubmed Abstract

Pubmed AbstractOpens New Window

Associated Topics

Related Publications

Physicians’ well-being linked to in-basket messages generated by algorithms In EHRs.

Tai-Seale M, Dillon EC, Yang Y, Nordgren R, Steinberg R, Nauenberg T, Lee TC, Meehan A, Li J, Chan AS, Frosch D.
Health Aff. 38(7): https://doi.org/10.1377/hlthaff.2018.05509.
2019 Jul 01

Physicians’ well-being linked to in-basket messages generated by algorithms In electronic health records.

Tai-Seale M, Dillon EC, Yang Y, Nordgren R, Steinberg R, Nauenberg T, Lee TC, Meehan A, Li J, Chan AS, Frosch D.
Health Aff. 38(7): https://doi.org/10.1377/hlthaff.2018.05509.
2019 Jul 01

Primary care provider utilization and satisfaction with a health system navigation program for adolescents with behavioral health needs.

Yang Y, Dillon EC, Li M, Li J, Erlich KJ, Heneghan AM, Becker DF.
Transl Behav Med. 9(3):549-559. doi: 10.1093/tbm/ibz049.
2019 May 16

Using electronic health record data to measure care quality for individuals with multiple chronic medical conditions.

Bayliss EA, McQuillan DB, Ellis JL, Maciejewski ML, Zeng C, Barton MB, Boyd CM, Fortin M, Ling SM, Tai-Seale M, Ralston JD, Ritchie CS, Zulman DM.
J Am Geriatr Soc. doi: 10.1111/jgs.14248. [Epub ahead of print]
2016 Jul 07

The Electronic CardioMetabolic Program (eCMP) for patients with cardiometabolic risk: a randomized controlled trial.

Azar KM, Koliwad S, Poon T, Xiao L, Lv N, Griggs R, Ma J.
J Med Internet Res. 18(5):e134. doi: 10.2196/jmir.5143.
2016 May 27