--- title: "Acute Ischemic Stroke Picasso | Sutter Health" description: "Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial" url: "https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Acute Ischemic Stroke Picasso # Acute Ischemic Stroke PICASSO **Status:** Open to Enrollment [Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#enroll) #### Study details View study details on [www.clinicaltrials.gov](https://www.clinicaltrials.gov/study/NCT05611242?term=NCT05611242&rank=1). #### Locations - San Francisco - Sacramento #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial (PICASSO). The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis). ![Fabio Settcase, M.D., M.S., FRCPC](https://dyn.mktgcdn.com/p/d17tD0cjo94MLtAnVdA9P13a1b735GWlmwDAzhXcfk8/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Fabio Settcase, M.D., M.S., FRCPC Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/fabio-settcase-md-ms-frcpc-1049681234) ![Matthew D Alexander, M.D.](https://dyn.mktgcdn.com/p/85YDjXP5NSWwCiJ8C9_8SVM_fnYErdB4Wk_9Nu4B34M/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Matthew D Alexander, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/matthew-d-alexander-md-1097247293) ## Email us to enroll - [Email San Francisco](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Acute%20Ischemic%20Stroke%20PICASSO%20in%20San%20Francisco&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email Sacramento](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Acute%20Ischemic%20Stroke%20PICASSO%20in%20Sacramento&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Stroke FASTEST](https://www.sutterhealth.org/research/clinical-trials/stroke-fastest-1049141798) Recombinant Factor VIIa (rFVIIa) for Acute Hemorrhagic Stroke Administered At Earliest Time (FASTEST) Trial **Status:** Open to Enrollment - Clinical trial ### [ALS Healey Platform Trial Master Protocol](https://www.sutterhealth.org/research/clinical-trials/als-healey-platform-trial-master-protocol-2057369170) HEALEY ALS Platform Trial **Status:** Closed to Enrollment - Clinical trial ### [ALS SPG302 Expanded Access Protocol](https://www.sutterhealth.org/research/clinical-trials/als-spg302-expanded-access-protocol-2036968358) Intermediate-size Patient Population Expanded Access Protocol for SPG302 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) **Status:** Open to Enrollment - Clinical trial ### [Amyotrophic Lateral Sclerosis (ALS) C302-CLN-2301](https://www.sutterhealth.org/research/clinical-trials/amyotrophic-lateral-sclerosis-als-c302-cln-2301-2044044761) Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, 24-Week Study With Additional 24-Week Blinded Active Extension to Evaluate the Safety and Efficacy of COYA 302 for the Treatment of Amyotrophic Lateral Sclerosis (ALS) **Status:** Open to Enrollment - Clinical trial ### [Amyotrophic Lateral Sclerosis (ALS) PL101-ALS301 PREVAILS](https://www.sutterhealth.org/research/clinical-trials/amyotrophic-lateral-sclerosis-als-pl101-als301-prevails-2064309735) A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Pridopidine in Participants With Amyotrophic Lateral Sclerosis **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Acute Ischemic Stroke Picasso"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#medicalwebpage","name":"Acute Ischemic Stroke PICASSO","description":"Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial","url":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919","inLanguage":"en-US","dateModified":"2026-05-19","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#breadcrumblist"},"mentions":[{"@type":"Person","name":"Fabio Settcase, M.D., M.S., FRCPC","url":"https://www.sutterhealth.org/research/investigators/fabio-settcase-md-ms-frcpc-1049681234","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}},{"@type":"Person","name":"Matthew D Alexander, M.D.","url":"https://www.sutterhealth.org/research/investigators/matthew-d-alexander-md-1097247293","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalTrial","@id":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919#medicaltrial","name":"Acute Ischemic Stroke PICASSO","alternateName":"Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial","url":"https://www.sutterhealth.org/research/clinical-trials/acute-ischemic-stroke-picasso-1094825919","description":"Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial (PICASSO). The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).","identifier":"NCT05611242","code":{"@type":"MedicalCode","codeValue":"NCT05611242","codingSystem":"ClinicalTrials.gov"},"sameAs":"https://www.clinicaltrials.gov/study/NCT05611242?term=NCT05611242&rank=1","status":"https://schema.org/Recruiting","healthCondition":[{"@type":"MedicalCondition","name":"Stroke"}],"studyLocation":[{"@type":"AdministrativeArea","name":"San Francisco"},{"@type":"AdministrativeArea","name":"Sacramento"}]} ```