--- title: "Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer CO45042 Krascendo 2 | Sutter Health" description: "A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer" url: "https://www.sutterhealth.org/research/clinical-trials/advanced-or-metastatic-non-squamous-non-small-cell-lung-cancer-co45042-krascendo-2-2064305186" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer CO45042 Krascendo 2 # Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer CO45042 Krascendo 2 **Status:** Open to Enrollment [Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/advanced-or-metastatic-non-squamous-non-small-cell-lung-cancer-co45042-krascendo-2-2064305186#enroll) #### Study details View study details on [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06793215). #### Locations - San Francisco - Mountain View - Palo Alto - San Mateo - Roseville - Sunnyvale #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). A Phase III, Randomized, Open-Label Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Patients With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer ![Kevin B Kim, M.D.](https://dyn.mktgcdn.com/p/c5YP2PezO8WGhQo-AyMNM4jgZenkBbfA9R6zjGEliTY/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Kevin B Kim, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/kevin-b-kim-md-1049681162) ## Sub-Investigators [Natalia Colocci, M.D., Ph.D.](https://www.sutterhealth.org/research/investigators/natalia-colocci-md-phd-1049680997) , [Dron Gauchan, M.D.](https://www.sutterhealth.org/research/investigators/dron-gauchan-md-1049681200) , [Julian H McLain, M.D.](https://www.sutterhealth.org/research/investigators/julian-h-mclain-md-2064304850) , [Kim-Son Nguyen, M.D., MPA](https://www.sutterhealth.org/research/investigators/kim-son-nguyen-md-mpa-1049681024) ## Email us to enroll - [Email San Francisco](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20San%20Francisco&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email Mountain View](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20Mountain%20View&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email Palo Alto](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20Palo%20Alto&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email San Mateo](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20San%20Mateo&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email Roseville](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20Roseville&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email Sunnyvale](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Advanced%20or%20Metastatic%20Non-Squamous%20Non-Small%20Cell%20Lung%20Cancer%20CO45042%20Krascendo%202%20in%20Sunnyvale&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Adjuvant Early-stage Non-small Cell Lung Cancer Beamion LUNG-3](https://www.sutterhealth.org/research/clinical-trials/adjuvant-early-stage-non-small-cell-lung-cancer-beamion-lung-3-2084403277) Beamion LUNG-3: A Randomized, Controlled, Multi-center Trial Evaluating Zongertinib as an Adjuvant Monotherapy Compared With Standard of Care in Patients With Early-stage, Resectable Non-small Cell Lung Cancer (Stage II-IIIB) Harboring Tyrosine Kinase Domain Activating HER2 Mutations **Status:** Open to Enrollment - Clinical trial ### [Adjuvant Monotherapy vs. Standard of Care Early-stage, Resectable Non-small Cell Lung Cancer](https://www.sutterhealth.org/research/clinical-trials/adjuvant-monotherapy-vs-standard-of-care-early-stage-resectable-non-small-cell-lung-cancer-2082765455) Beamion LUNG-3: A Randomized, Controlled, Multi-center Trial Evaluating Zongertinib as an Adjuvant Monotherapy Compared With Standard of Care in Patients With Early-stage, Resectable Non-small Cell Lung Cancer (Stage II-IIIB) Harboring Tyrosine Kinase Domain Activating HER2 Mutations **Status:** Coming Soon - Clinical trial ### [Adjuvant Non Small Lung Cancer TroFuse-019](https://www.sutterhealth.org/research/clinical-trials/adjuvant-non-small-lung-cancer-trofuse-019-2015848648) A Phase 3 Randomized Open-Label Study of Adjuvant Pembrolizumab With or Without MK-2870 in Participants With Resectable Stage II to IIIB (N2) NSCLC Not Achieving pCR After Receiving Neoadjuvant Pembrolizumab With Platinum-based Doublet Chemotherapy Followed by Surgery (MK-2870-019) (TroFuse-019) **Status:** Open to Enrollment - Clinical trial ### [Adjuvant Non-Small Cell Lung Cancer A081801](https://www.sutterhealth.org/research/clinical-trials/adjuvant-non-small-cell-lung-cancer-a081801-1049141795) Integration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO **Status:** Open to Enrollment - Clinical trial ### [Adjuvant Non-Small-Cell Lung Cancer C5851005 PADL1NK-005](https://www.sutterhealth.org/research/clinical-trials/adjuvant-non-small-cell-lung-cancer-c5851005-padl1nk-005-2064313501) PADL1NK-005: A Randomized, Phase 3, Open-Label Study to Evaluate PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC) **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json 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