--- title: "Cardiovascular Disease LAAOS-4 | Sutter Health" description: "The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)" url: "https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Cardiovascular Disease LAAOS-4 # Cardiovascular Disease LAAOS-4 **Status:** Open to Enrollment [Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287#enroll) #### Study details View study details on [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05963698?term=LAAOS-4&rank=1). #### Locations - Sacramento #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). LAAOS-4 is a multicentre, prospective, open-label, randomized controlled trial with blinded assessment of endpoints (PROBE) to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation. ![David K. Roberts, III, M.D.](https://dyn.mktgcdn.com/p/YGB9hVSueHYwCgM9d1K_1I_9tGq2g3wbJpYQPHkB39o/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) David K. Roberts, III, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/david-k-roberts-iii-md-1049681069) ## Sub-Investigator [Pei-Hsiu Huang, M.D.](https://www.sutterhealth.org/research/investigators/pei-hsiu-huang-md-1049681044) ## Email us to enroll - [Email Sacramento](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Cardiovascular%20Disease%20LAAOS-4%20in%20Sacramento&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Cardiovascular Global Paradise System US Post Approval Study (US GPS)](https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543) The Global Paradise® System US Post Approval Study (US GPS) **Status:** Open to Enrollment - Clinical trial ### [Severe Tricuspid Valve Regurgitation VDyne Transcatheter Tricuspid Valve Replacement CIP-CL-001 TRIVITA](https://www.sutterhealth.org/research/clinical-trials/severe-tricuspid-valve-regurgitation-vdyne-transcatheter-tricuspid-valve-replacement-cip-cl-001-trivita-2092096598) VDyne Transcatheter Tricuspid Valve Replacement Study to Evaluate Safety and Clinical Efficacy in Patients With Symptomatic Severe Tricuspid Valve Regurgitation **Status:** Open to Enrollment - Clinical trial ### [Aortic Stenosis with TAVI ET03 SHIELD](https://www.sutterhealth.org/research/clinical-trials/aortic-stenosis-with-tavi-et03-shield-2084630343) A Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve Replacement **Status:** Coming Soon - Clinical trial ### [Mitral Regurgitation - Transcatheter Mitral Valve Replacement (TMVR) ATLAS Alta Valve](https://www.sutterhealth.org/research/clinical-trials/structural-heart-alta-valve-1078067771) AltaValve Pivotal Trial **Status:** Open to Enrollment - Clinical trial ### [Mitral Valve Regurgitation TMVR APOLLO Trial](https://www.sutterhealth.org/research/clinical-trials/mitral-valve-regurgitation-tmvr-apollo-trial-1095561609) Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO Trial **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Cardiovascular Disease LAAOS-4"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287#medicalwebpage","name":"Cardiovascular Disease LAAOS-4","description":"The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)","url":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287","inLanguage":"en-US","dateModified":"2026-05-21","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287#breadcrumblist"},"mentions":[{"@type":"Person","name":"David K. 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