--- title: "Cardiovascular Global Paradise System US Post Approval Study (US GPS) | Sutter Health" description: "The Global Paradise® System US Post Approval Study (US GPS)" url: "https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Cardiovascular Global Paradise System US Post Approval Study (US GPS) # Cardiovascular Global Paradise System US Post Approval Study (US GPS) **Status:** Open to Enrollment [Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#enroll) #### Study details View study details on [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06297291). #### Locations - Sacramento #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a catheter, cable, balloon, and generator and has received FDA approval in the United States. Information collected in this study will be analyzed to better understand the long-term safety and effectiveness of treatment with the Paradise System for patients with high blood pressure. Please contact: [ClinicalResearch@sutterhealth.org](mailto:ClinicalResearch@sutterhealth.org) about the study. ![Powell O Jose, M.D., FACC](https://dyn.mktgcdn.com/p/dcVZsXUEAlS200Rj1HxJe0cSiIuLGdzV2CNegTEDHmk/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Powell O Jose, M.D., FACC Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/powell-o-jose-md-facc-1049681010) ## Sub-Investigators [Pei-Hsiu Huang, M.D.](https://www.sutterhealth.org/research/investigators/pei-hsiu-huang-md-1049681044) , [Syed Latif, M.D., FACC](https://www.sutterhealth.org/research/investigators/syed-latif-md-facc-1049681256) , [David K. Roberts, III, M.D.](https://www.sutterhealth.org/research/investigators/david-k-roberts-iii-md-1049681069) ## Email us to enroll - [Email Sacramento](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Cardiovascular%20Global%20Paradise%20System%20US%20Post%20Approval%20Study%20\(US%20GPS\)%20in%20Sacramento&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Cardiovascular Disease LAAOS-4](https://www.sutterhealth.org/research/clinical-trials/cardiovascular-disease-laaos-4-2005599287) The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4) **Status:** Open to Enrollment - Clinical trial ### [Severe Tricuspid Valve Regurgitation VDyne Transcatheter Tricuspid Valve Replacement CIP-CL-001 TRIVITA](https://www.sutterhealth.org/research/clinical-trials/severe-tricuspid-valve-regurgitation-vdyne-transcatheter-tricuspid-valve-replacement-cip-cl-001-trivita-2092096598) VDyne Transcatheter Tricuspid Valve Replacement Study to Evaluate Safety and Clinical Efficacy in Patients With Symptomatic Severe Tricuspid Valve Regurgitation **Status:** Open to Enrollment - Clinical trial ### [Aortic Stenosis with TAVI ET03 SHIELD](https://www.sutterhealth.org/research/clinical-trials/aortic-stenosis-with-tavi-et03-shield-2084630343) A Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve Replacement **Status:** Coming Soon - Clinical trial ### [Mitral Regurgitation - Transcatheter Mitral Valve Replacement (TMVR) ATLAS Alta Valve](https://www.sutterhealth.org/research/clinical-trials/structural-heart-alta-valve-1078067771) AltaValve Pivotal Trial **Status:** Open to Enrollment - Clinical trial ### [Mitral Valve Regurgitation TMVR APOLLO Trial](https://www.sutterhealth.org/research/clinical-trials/mitral-valve-regurgitation-tmvr-apollo-trial-1095561609) Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO Trial **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Cardiovascular Global Paradise System US Post Approval Study (US GPS)"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#medicalwebpage","name":"Cardiovascular Global Paradise System US Post Approval Study (US GPS)","description":"The Global Paradise® System US Post Approval Study (US GPS)","url":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543","inLanguage":"en-US","dateModified":"2026-05-19","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#breadcrumblist"},"mentions":[{"@type":"Person","name":"Powell O Jose, M.D., FACC","url":"https://www.sutterhealth.org/research/investigators/powell-o-jose-md-facc-1049681010","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalTrial","@id":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543#medicaltrial","name":"Cardiovascular Global Paradise System US Post Approval Study (US GPS)","alternateName":"The Global Paradise® System US Post Approval Study (US GPS)","url":"https://www.sutterhealth.org/research/clinical-trials/cardiovascular-recor-us-gps-1084355543","description":"The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. 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