---
title: "Neoadjuvant Glioblastoma GTM-105 | Sutter Health"
description: "Randomized Study of Resection and GammaTile® Followed by Concurrent External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ Versus Standard of Care in Newly Diagnosed Glioblastoma (GBM)"
url: "https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544"
---

1.  [Home](https://www.sutterhealth.org/) /
2.  [Research](https://www.sutterhealth.org/research) /
3.  [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) /
4.  Neoadjuvant Glioblastoma GTM-105

# Neoadjuvant Glioblastoma GTM-105

**Status:** Open to Enrollment

[Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#enroll)

#### Study details

View study details on [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07195591).

#### Locations

-   San Francisco

#### Clinical trial FAQs

Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs).

Randomized Study of Resection and GammaTile® Followed by Concurrent External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ Versus Standard of Care in Newly Diagnosed Glioblastoma (GBM)

![Patricia L Seid, M.D.](https://dyn.mktgcdn.com/p/uIixwd6UEKUz_duaDGD2p_pZWj-SybkqA2RecU1QAME/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100)

Patricia L Seid, M.D.

Principal investigator

[View profile](https://www.sutterhealth.org/research/investigators/patricia-l-seid-md-2084465240)

## Sub-Investigators

[Lewis Z Leng, M.D., FAANS](https://www.sutterhealth.org/research/investigators/lewis-z-leng-md-faans-1049681102) , [Akanksha Sharma, M.D.](https://www.sutterhealth.org/research/investigators/akanksha-sharma-md-2066909098) , [Roy E Abendroth, M.D., FACR](https://www.sutterhealth.org/research/investigators/roy-e-abendroth-md-facr-2084465267) , [Michael Y Zhang, M.D., PhD](https://www.sutterhealth.org/research/investigators/michael-y-zhang-md-phd-2084465285) , [John W Lee, M.D.](https://www.sutterhealth.org/research/investigators/john-w-lee-md-1049681224)

## Email us to enroll

-   [Email San Francisco](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Neoadjuvant%20Glioblastoma%20GTM-105%20in%20San%20Francisco&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.)

## Related clinical trials

[View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial)

-   Clinical trial
    
    ### [Recurrent or Progressive IDH1 Mutated Glioma NEO100-01](https://www.sutterhealth.org/research/clinical-trials/recurrent-or-progressive-idh1-mutated-glioma-neo100-01-2066909715)
    
    An Open-Label, Phase 1/2A Dose Escalation Study of Safety and Efficacy of NEO100 in Recurrent or Progressive Grade III or Grade IV Gliomas With IDH1 Mutation
    
    **Status:** Open to Enrollment
    
-   Clinical trial
    
    ### [Advanced Cervical Cancer NRG GY037](https://www.sutterhealth.org/research/clinical-trials/advanced-cervical-cancer-nrg-gy037-2097344123)
    
    A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab vs Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer
    
    **Status:** Open to Enrollment
    
-   Clinical trial
    
    ### [Advanced Staged Cancer Targeted Therapy ASCO TAPUR](https://www.sutterhealth.org/research/clinical-trials/targeted-agent-and-profiling-utilization-registry-tapur-st-1049141787)
    
    Targeted Agent and Profiling Utilization Registry (TAPUR) Study
    
    **Status:** Open to Enrollment
    
-   Clinical trial
    
    ### [Adverse Effects of Chemotherapy Shengbai Solution](https://www.sutterhealth.org/research/clinical-trials/adverse-effects-of-chemotherapy-shengbai-solution-1097505286)
    
    A Randomized, Blinded, Placebo-controlled Trial of Shengbai Oral Formula to Assess Safety and Alleviation of Adverse Effects in Patients With Cancer Undergoing Chemotherapy
    
    **Status:** Open to Enrollment
    
-   Clinical trial
    
    ### [Acute Myeloid Leukemia Dental Wipes COG ACCL2531](https://www.sutterhealth.org/research/clinical-trials/acute-myeloid-leukemia-dental-wipes-cog-accl2531-2099128841)
    
    A Randomized Double-Blinded Trial of Xylitol Dental Wipes for the Prophylaxis of Bloodstream Infections From Oral Organisms in Pediatric Patients With Acute Myeloid Leukemia
    
    **Status:** Open to Enrollment
    

[View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial)

```json
{"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]}
```

```json
{"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Neoadjuvant Glioblastoma GTM-105"}]}
```

```json
{"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#medicalwebpage","name":"Neoadjuvant Glioblastoma GTM-105","description":"Randomized Study of Resection and GammaTile® Followed by Concurrent External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ Versus Standard of Care in Newly Diagnosed Glioblastoma (GBM)","url":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544","inLanguage":"en-US","dateModified":"2026-10-19","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#breadcrumblist"},"mentions":[{"@type":"Person","name":"Patricia L Seid, M.D.","url":"https://www.sutterhealth.org/research/investigators/patricia-l-seid-md-2084465240","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}}]}
```

```json
{"@context":"https://schema.org","@type":"MedicalTrial","@id":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544#medicaltrial","name":"Neoadjuvant Glioblastoma GTM-105","alternateName":"Randomized Study of Resection and GammaTile® Followed by Concurrent External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ Versus Standard of Care in Newly Diagnosed Glioblastoma (GBM)","url":"https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-glioblastoma-gtm-105-2084413544","description":"Randomized Study of Resection and GammaTile® Followed by Concurrent External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ Versus Standard of Care in Newly Diagnosed Glioblastoma (GBM)","identifier":"NCT07195591","code":{"@type":"MedicalCode","codeValue":"NCT07195591","codingSystem":"ClinicalTrials.gov"},"sameAs":"https://clinicaltrials.gov/study/NCT07195591","status":"https://schema.org/Recruiting","healthCondition":[{"@type":"MedicalCondition","name":"Glioblastoma"}],"studyLocation":[{"@type":"AdministrativeArea","name":"San Francisco"}]}
```
