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Content

Neoadjuvant (SWOG S1826)

Study Information

Status: Active, Recruiting

Study Details

View study details on clinicaltrials.gov.

Locations

Greater Sacramento Valley

Clinical Trial FAQs

Information for patients and study volunteers, including frequently asked questions.

Contact Us to Enroll

Description

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to cancer cells in a targeted way and delivers vedotin to kill them. Chemotherapy drugs, such as doxorubicin, vinblastine, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of nivolumab or brentuximab vedotin to combination chemotherapy may shrink the cancer or extend the time without disease symptoms coming back.

Principal Investigator

Yung Soon Yim, MD

Co-Investigator(s)

YiSheng Lee, M.D., Saunders C. Hsu, M.D 

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