--- title: "Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP | Sutter Health" description: "The PROGRESS Trial: A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement" url: "https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP # Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP **Status:** Open to Enrollment [Email us to enroll](https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#enroll) #### Study details View study details on [classic.clinicaltrials.gov](https://classic.clinicaltrials.gov/ct2/show/NCT04889872?term=progress&cond=moderate+stenosis&draw=2&rank=1). #### Locations - Berkeley - San Francisco #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial. ![David V Daniels, M.D.](https://dyn.mktgcdn.com/p/4FqLGwv5l5KnP42Q-6toojBNRGEKTDrprUK_xsYZSo8/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) David V Daniels, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/david-v-daniels-md-1049681155) ## Sub-Investigators [Brett C Sheridan, M.D.,FACS](https://www.sutterhealth.org/research/investigators/brett-c-sheridan-mdfacs-1049681181) , [Christian Spies, M.D.](https://www.sutterhealth.org/research/investigators/christian-spies-md-1078064875) ## Email us to enroll - [Email Berkeley](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Moderate%20Aortic%20Stenosis%20-%20Transcatheter%20Aortic%20Valve%20Replacement%20\(TAVR\)%20PROGRESS%20CAP%20in%20Berkeley&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) - [Email San Francisco](mailto:ClinicalResearch%40sutterhealth.org?subject=More%20information%20on%20Moderate%20Aortic%20Stenosis%20-%20Transcatheter%20Aortic%20Valve%20Replacement%20\(TAVR\)%20PROGRESS%20CAP%20in%20San%20Francisco&body=Please%20be%20aware%20that%20if%20you%20reply%20with%20unencrypted%20email%2C%20this%20increases%20the%20risk%20that%20information%20could%20be%20read%20by%20an%20unauthorized%20third%20party.%20Please%20do%20not%20include%20any%20Protected%20Health%20Information%20in%20your%20email%20response.) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Aortic Stenosis Severe SAPIEN X4 Transcatheter Heart Valve ALLIANCE](https://www.sutterhealth.org/research/clinical-trials/aortic-stenosis-severe-sapien-x4-transcatheter-heart-valve-alliance-2080559769) Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve **Status:** Open to Enrollment - Clinical trial ### [Aortic Valve Stenosis SAPIEN X4 Transcatheter Heart Valve ALLIANCE-AVIV](https://www.sutterhealth.org/research/clinical-trials/aortic-valve-stenosis-sapien-x4-transcatheter-heart-valve-alliance-aviv-2080559940) Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves **Status:** Open to Enrollment - Clinical trial ### [REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE-RESTORE](https://www.sutterhealth.org/research/clinical-trials/redo-transcatheter-aortic-valve-replacement-for-transcatheter-aortic-valve-failure-restore-2057384076) REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE **Status:** Open to Enrollment - Clinical trial ### [Aortic Stenosis with TAVI ET03 SHIELD](https://www.sutterhealth.org/research/clinical-trials/aortic-stenosis-with-tavi-et03-shield-2084630343) A Prospective, Randomized, Multicenter, Single-blind Trial to Assess the Safety and Effectiveness of the Encompass F2 Cerebral Protection System Vs. Standard of Care (Unprotected or Sentinel® Cerebral Protection System) During Transfemoral Transcatheter Aortic Valve Replacement **Status:** Coming Soon - Clinical trial ### [Mitral Regurgitation - Transcatheter Mitral Valve Replacement (TMVR) ATLAS Alta Valve](https://www.sutterhealth.org/research/clinical-trials/structural-heart-alta-valve-1078067771) AltaValve Pivotal Trial **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#medicalwebpage","name":"Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP","description":"The PROGRESS Trial: A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement","url":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769","inLanguage":"en-US","dateModified":"2026-05-19","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#breadcrumblist"},"mentions":[{"@type":"Person","name":"David V Daniels, M.D.","url":"https://www.sutterhealth.org/research/investigators/david-v-daniels-md-1049681155","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalTrial","@id":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769#medicaltrial","name":"Moderate Aortic Stenosis - Transcatheter Aortic Valve Replacement (TAVR) PROGRESS CAP","alternateName":"The PROGRESS Trial: A Prospective, Randomized, Controlled Trial to Assess the Management of Moderate Aortic Stenosis by Clinical Surveillance or Transcatheter Aortic Valve Replacement","url":"https://www.sutterhealth.org/research/clinical-trials/progress-cap-1078067769","description":"This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis. 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