--- title: "Recurrent Glioblastoma SC9-GBM-03 | Sutter Health" description: "A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma." url: "https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Clinical trials](https://www.sutterhealth.org/research/clinical-trials) / 4. Recurrent Glioblastoma SC9-GBM-03 # Recurrent Glioblastoma SC9-GBM-03 **Status:** Closed to Enrollment #### Study details View study details on [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT05902169). #### Locations - San Francisco #### Clinical trial FAQs Information for patients and study volunteers, including [frequently asked questions](https://www.sutterhealth.org/research/faqs). A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma. ****TEMPORARILY CLOSED TO ENROLLMENT**** ![Lewis Z Leng, M.D., FAANS](https://dyn.mktgcdn.com/p/UonDQ7rUsnlT5tXZbxiSVdy8-rp687k4M4G4K2QFIxg/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Lewis Z Leng, M.D., FAANS Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/lewis-z-leng-md-faans-1049681102) ## Sub-Investigators [Lin Wang, M.D., Ph.D.](https://www.sutterhealth.org/research/investigators/lin-wang-md-phd-2036971410) , [Akanksha Sharma, M.D.](https://www.sutterhealth.org/research/investigators/akanksha-sharma-md-2066909098) ## Related clinical trials [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) - Clinical trial ### [Adjuvant Astrocytomas Grade 3 A072301](https://www.sutterhealth.org/research/clinical-trials/adjuvant-astrocytomas-grade-3-a072301-2082117649) Phase III Trial of Radiotherapy Followed by Adjuvant Temozolomide in Combination With the IDH Inhibitor Vorasidenib vs Placebo in IDH-Mutated Newly-Diagnosed Grade 3 Astrocytomas **Status:** Open to Enrollment - Clinical trial ### [Metastasis Brain NEO212-01](https://www.sutterhealth.org/research/clinical-trials/metastasis-brain-neo212-01-2079170524) An Open-label Phase 1/2 Dose Finding, Safety and Efficacy Study of Oral NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Uncontrolled Brain Metastasis in Patients With Select Solid Tumors **Status:** Open to Enrollment - Clinical trial ### [Neoadjuvant Neuroblastoma ANBL2131](https://www.sutterhealth.org/research/clinical-trials/neoadjuvant-neuroblastoma-anbl2131-2022194957) A Phase 3 Study of Dinutuximab Added to Intensive Multimodal Therapy for Children With Newly Diagnosed High-Risk Neuroblastoma **Status:** Open to Enrollment - Clinical trial ### [Recurrent or Progressive IDH1 Mutated Glioma NEO100-01](https://www.sutterhealth.org/research/clinical-trials/recurrent-or-progressive-idh1-mutated-glioma-neo100-01-2066909715) An Open-Label, Phase 1/2A Dose Escalation Study of Safety and Efficacy of NEO100 in Recurrent or Progressive Grade III or Grade IV Gliomas With IDH1 Mutation **Status:** Open to Enrollment - Clinical trial ### [Residual, Progressive or Recurrent Grade II or III Meningioma NEO100-02](https://www.sutterhealth.org/research/clinical-trials/residual-progressive-or-recurrent-grade-ii-or-iii-meningioma-neo100-02-2066911166) An Open-Label, Phase 2 Study of NEO100 in Participants With Residual, Progressive or Recurrent High-Grade Meningioma **Status:** Open to Enrollment [View all clinical trials](https://www.sutterhealth.org/research-search-results?verticalKey=clinical_trial) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Clinical trials","item":"https://www.sutterhealth.org/research/clinical-trials"},{"@type":"ListItem","position":4,"name":"Recurrent Glioblastoma SC9-GBM-03"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalWebPage","@id":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836#medicalwebpage","name":"Recurrent Glioblastoma SC9-GBM-03","description":"A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.","url":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836","inLanguage":"en-US","dateModified":"2026-10-26","publisher":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"},"medicalAudience":{"@type":"MedicalAudience","audienceType":"Patient"},"mainEntity":{"@id":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836#medicaltrial"},"breadcrumb":{"@id":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836#breadcrumblist"},"mentions":[{"@type":"Person","name":"Lewis Z Leng, M.D., FAANS","url":"https://www.sutterhealth.org/research/investigators/lewis-z-leng-md-faans-1049681102","jobTitle":"Principal Investigator","affiliation":{"@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org"}}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalTrial","@id":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836#medicaltrial","name":"Recurrent Glioblastoma SC9-GBM-03","alternateName":"A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma.","url":"https://www.sutterhealth.org/research/clinical-trials/recurrent-glioblastoma-sc9-gbm-03-2064304836","description":"A Randomized, Open-label, Multicentric, Two-arm Pivotal Trial of SonoCloud-9 Combined With Carboplatin (CBDCA) vs Standard of Care Lomustine (CCNU) or Temozolomide (TMZ) in Patients Undergoing Planned Resection for First Recurrence Glioblastoma. 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