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The TESLA Trial: Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke

Study Information

Status: Active, Recruiting

Study Details

View study details on clinicaltrials.gov.

Locations

Greater Sacramento Valley, San Francisco

Clinical Trial FAQs

Information for patients and study volunteers, including frequently asked questions.

Contact Us to Enroll

Description

The primary objective of the trial is to establish the effectiveness of IAT (versus medical management) in patients with moderate-large infarcts (NCCT ASPECTS 2-5) at baseline, with adaptive enrichment to better define the upper limit of infarct volume for treatment eligibility. Furthermore, the investigators aim to determine whether certain subgroups of patients with large baseline infarcts will have a greater treatment benefit. Finally, the investigators will assess the agreement of ASPECTS scores between site investigators, the core imaging lab, and automated software.

Prospective, randomized, open-label, blinded endpoint study. Patients presenting with symptoms of AIS who have evidence of a moderate-large infarct volume (Non-contrast CT Alberta Stroke Program Early CT score [NCCT ASPECTS] 2-5 in the anterior circulation will be assigned to either best medical management alone (including IV rtPA) or intra-arterial treatment (IAT) with mechanical thrombectomy added to best medical management. Each treated patient will be followed and assessed for 3 months after randomization.

SIMR (Sacramento/Valley Area): Please contact SIMR@sutterhealth.org about study The Tesla Trial

CPMC (San Francisco: Davies & Van Ness): Please contact clinicalresearch@sutterhealth.org about study The Tesla Trial

MPMC (Mills Peninsula-Burlingame): Please contact clinicalresearch@sutterhealth.org about study The Tesla Trial

Principal Investigator

Rajkamal Khangura, MD

Co-Investigator(s)

Manoj K. Mittal, M.D. 

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