--- title: "Advances in mgmt of chronic obstructive pulmonary disease. | Sutter Health" description: "COPD mgmt should involve a multi-pronged approach: smoking cessation, bronchodilators, infection tx, target inflammatory pathways/genetic predispositions." url: "https://www.sutterhealth.org/research/publications/advances-mgmt-copd-1055312934" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Advances in mgmt of chronic obstructive pulmonary disease. # Advances in the management of chronic obstructive pulmonary disease. Meinke L, Chitkara R, & Krishna G. _Expert Opin Pharmacother. 8(1):23-37._ 2007-01-01 ## Abstract Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death, seems to be increasing in worldwide prevalence, and carries with it a significant health and economic burden. Smoking cessation is the only available intervention proven to halt disease progression. The authors discuss the role of the newly approved agent, varenicline, in promotion of smoking cessation. The remainder of presently available therapies treat the symptoms of COPD, but do not impact progression of disease. As the understanding of the pathogenesis of COPD improves, new targets for therapies are emerging. Given the large number of potential targets and the results of recent studies, it seems unlikely that a single new agent will result in a cure. Rather, management of COPD should involve a multi-pronged approach including smoking cessation, bronchodilators, treatment of infection, and eventual targeting of inflammatory pathways and genetic predispositions. In this article, the authors discuss presently available therapies as well as agents under development. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/?term=Meinke+L%2C+Chitkara+R) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: the RENEW randomized clinical trial.](https://www.sutterhealth.org/research/publications/endobronchial-coils-severe-emphysema-trial-1055312472) Sciurba FC, Criner GJ, Strange C, Shah PL, Michaud G, Connolly TA, Deslée G, Tillis WP, Delage A, Marquette CH, Krishna G, Kalhan R, Ferguson JS, Jantz M, Maldonado F, McKenna R, Majid A, Rai N, Gay S, Dransfield MT, Angel L, Maxfield R, Herth FJ, Wahidi MM, Mehta A, Slebos DJ; RENEW Study Research Group. JAMA. 315(20):2178-2189. doi: 10.1001/jama.2016.6261. 2016 May 24 - Publication ### [A 35-year-old man with fever, dyspnea, and diffuse reticular opacities.](https://www.sutterhealth.org/research/publications/35-yo-man-fever-dyspnea-reticular-oopacities-1055312816) Katikireddy CK, Krishna G, Keifer T, Kuschner W, Rosen G. Chest. 129(2):482-7. 2006 Feb 01 - Publication ### [The dying thoracic patient.](https://www.sutterhealth.org/research/publications/dying-thoracic-patient-1055312967) Krishna G, Raffin TA. Chest Surg Clin N Am. 8(3):723-39. 1998 Aug 01 - Publication ### [Parasitic pulmonary eosinophilia.](https://www.sutterhealth.org/research/publications/parasitic-pulmonary-eosinophilia-1055312949) Chitkara RK, Krishna G. Semin Respir Crit Care Med. 27(2):171-84. 2006 Apr 01 - Publication ### [Endobronchial ultrasound-guided transbronchial needle injection of liposomal amphotericin B for the treatment of symptomatic aspergilloma.](https://www.sutterhealth.org/research/publications/endobrachial-injection-amphotericin-b-aspergilloma-1055312303) Parikh MS, Seeley E, Nguyen-Tran E, Krishna G. J Bronchology Interv Pulmonol. doi: 10.1097/LBR.0000000000000383. \[Epub ahead of print\] 2017 Jun 05 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/advances-mgmt-copd-1055312934#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Advances in mgmt of chronic obstructive pulmonary disease."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/advances-mgmt-copd-1055312934#medicalscholarlyarticle","name":"Advances in the management of chronic obstructive pulmonary disease.","headline":"Advances in mgmt of chronic obstructive pulmonary disease.","abstract":"Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death, seems to be increasing in worldwide prevalence, and carries with it a significant health and economic burden. 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