--- title: "Asthma Impact on Quality of LIfe Scale: performance in pops. | Sutter Health" description: "Asthma Impact on Quality if Life Scale (A-IOQLS) is valid for research, and potentially clinical, use in demographically and clinically diverse patients." url: "https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Asthma Impact on Quality of LIfe Scale: performance in pops. # Performance of the Asthma Impact on Quality of Life Scale (A-IQOLS) in diverse asthma research populations and demographic sub-groups. Wilson SR, Wise RA, Castro M, Mulligan MJ, Ayala E, Chausow A, Huang Q, & Gummidipundi S. _J Allergy Clin Immunol. pii: S0091-6749(18)30634-1. doi: 10.1016/j.jaci.2018.02.056. \[Epub ahead of print\]_ 2018-05-03 ## Abstract BACKGROUND: The Asthma Impact on Quality of Life Scale (A-IQOLS) assesses patient-perceived negative effect of asthma on quality of life (QoL). Its standard error of measurement is known, it has strong construct, convergent, and divergent validity, and provides information that is unique among asthma outcome measures. OBJECTIVE: To characterize A-IQOLS' psychometric properties and suitability for use in demographically and clinically diverse adult asthma populations. METHODS: Data from participants in five independent asthma studies, whose samples ranging from patients with well-controlled moderate asthma to patients with severe, poorly controlled asthma were pooled to determine the psychometric performance of A-IQOLS scores, overall and in multiple demographic, disease status, and study subgroups. RESULTS: Pooled sample (n = 597) age averaged 45 years; 66% were female, 65% were White, 22% African American, 11% Hispanic, and 11% had ≤ high school education. The rated importance of its underlying life dimensions and the associations between A-IQOLS scores and lung function, symptoms, ACT, Juniper Mini-AQLQ, and Marks AQLQ scores was very similar regardless of patient demographic and clinical characteristics. A-IQOLS scores discriminated among the individual study samples as well as other patient-reported symptom and functional status measures. Distribution and anchor-based considerations suggest an A-IQOLS minimum clinically important difference (MID) in the vicinity of 0.50, and not smaller than 0.33, scale score units. CONCLUSIONS: A-IQOLS is valid for research, and potentially clinical, use in demographically and clinically diverse patients. [PubMed abstract](https://www.ncbi.nlm.nih.gov/pubmed/29729942) ## Research topics - [Asthma](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Asthma%5C%22%22) - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Pilot randomised trial of a healthy eating behavioural intervention in uncontrolled asthma.](https://www.sutterhealth.org/research/publications/pilot-trial-healthy-eating-uncontrolled-asthma-1055312944) Ma J, Strub P, Lv N, Xiao L, Camargo CA Jr, Buist AS, Lavori PW, Wilson SR, Nadeau KC, Rosas LG. Eur Respir J. pii: ERJ-00591-2015. doi: 10.1183/13993003.00591-2015. \[Epub ahead of print\] 2015 Oct 22 - Publication ### [American Thoracic Society and National Heart, Lung, and Blood Institute Implementation Research Workshop Report.](https://www.sutterhealth.org/research/publications/ats-nhlbi-implementation-research-wkshop-report-1055312327) Bender BG, Krishnan JA, Chambers DA, Cloutier MM, Riekert KA, Rand CS, Schatz M, Thomson CC, Wilson SR, Apter A, Carson SS, George M, Gerald JK, Gerald L, Goss CH, Okelo SO, Mularski RA, Nguyen HQ, Patel MR, Szefler SJ, Weiss CH, Wilson KC, Freemer M. Ann Am Thorac Soc. 2015 Dec;12(12):S213-21. doi: 10.1513/AnnalsATS.201506-367OT. 2015 Dec 12 - Publication ### [Patient dose simulations for scanning-beam digital x-ray tomosynthesis of the lungs.](https://www.sutterhealth.org/research/publications/pt-dose-simulations-sbdx-lung-tomosynthesis-1055312925) Nelson G, Yoon S, Krishna G, Wilfley B, Fahrig R. Med Phys. 40(11):111917. doi: 10.1118/1.4826159. 2013 Nov 01 - Publication ### [Minimally invasive techniques for the diagnosis of peripheral pulmonary nodules.](https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945) Krishna G, Gould MK. Curr Opin Pulm Med. 14(4):282-6. doi: 10.1097/MCP.0b013e328303df1b. 2008 Jul 01 - Publication ### [The diagnostic yield of navigational bronchoscopy performed with propofol deep sedation.](https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849) Mohanasundaram U, Ho LA, Kuschner WG, Chitkara RK, Canfield J, Canfield LM, Krishna G. Endoscopy. 2013 (Article ID 824693): 5 pages 2013 Jun 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Asthma Impact on Quality of LIfe Scale: performance in pops."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339#medicalscholarlyarticle","name":"Performance of the Asthma Impact on Quality of Life Scale (A-IQOLS) in diverse asthma research populations and demographic sub-groups.","headline":"Asthma Impact on Quality of LIfe Scale: performance in pops.","abstract":"BACKGROUND: The Asthma Impact on Quality of Life Scale (A-IQOLS) assesses patient-perceived negative effect of asthma on quality of life (QoL). Its standard error of measurement is known, it has strong construct, convergent, and divergent validity, and provides information that is unique among asthma outcome measures. OBJECTIVE: To characterize A-IQOLS' psychometric properties and suitability for use in demographically and clinically diverse adult asthma populations. METHODS: Data from participants in five independent asthma studies, whose samples ranging from patients with well-controlled moderate asthma to patients with severe, poorly controlled asthma were pooled to determine the psychometric performance of A-IQOLS scores, overall and in multiple demographic, disease status, and study subgroups. RESULTS: Pooled sample (n = 597) age averaged 45 years; 66% were female, 65% were White, 22% African American, 11% Hispanic, and 11% had ≤ high school education. The rated importance of its underlying life dimensions and the associations between A-IQOLS scores and lung function, symptoms, ACT, Juniper Mini-AQLQ, and Marks AQLQ scores was very similar regardless of patient demographic and clinical characteristics. A-IQOLS scores discriminated among the individual study samples as well as other patient-reported symptom and functional status measures. Distribution and anchor-based considerations suggest an A-IQOLS minimum clinically important difference (MID) in the vicinity of 0.50, and not smaller than 0.33, scale score units. CONCLUSIONS: A-IQOLS is valid for research, and potentially clinical, use in demographically and clinically diverse patients.","description":"Asthma Impact on Quality if Life Scale (A-IOQLS) is valid for research, and potentially clinical, use in demographically and clinically diverse patients.","keywords":["Asthma","Lung Diseases"],"datePublished":"2018-05-03","url":"https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"29729942"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1016/j.jaci.2018.02.056"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/29729942/","https://doi.org/10.1016/j.jaci.2018.02.056"],"isPartOf":{"@type":"Periodical","name":"J Allergy Clin Immunol"},"author":[{"@type":"Person","name":"Wilson SR"},{"@type":"Person","name":"Wise RA"},{"@type":"Person","name":"Castro M"},{"@type":"Person","name":"Mulligan MJ"},{"@type":"Person","name":"Ayala E"},{"@type":"Person","name":"Chausow A"},{"@type":"Person","name":"Huang Q"},{"@type":"Person","name":"Gummidipundi S"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Asthma","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Asthma%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Lung Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Lung+Diseases%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339#breadcrumblist"}}} ```