--- title: "Brain regions showing increased activation | Sutter Health" description: "Brain regions showing increased activation by threat-related words in panic disorder." url: "https://www.sutterhealth.org/research/publications/brainregionsshowingincreasedactivation-1055312756" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Brain regions showing increased activation # Brain regions showing increased activation by threat-related words in panic disorder. Maddock RJ1, Buonocore MH, Kile SJ, Garrett AS. Author information 1Department of Radiology, University of California Davis, 4801 X St, Sacramento, California 95817, & USA. rjmaddock@ucdaris.edu _Neuroreport. 2003 Mar_ 2003-03-20 ## Abstract Abstract Threat-related stimuli consistently activate the posterior cingulate cortex in normal subjects and have exaggerated effects on memory in patients with panic disorder. We hypothesized that panic patients would show increased response to threat-related stimuli in the posterior cingulate cortex. While undergoing fMRI, six panic patients and eight healthy volunteers made valence judgments of threat-related and neutral words. Both groups showed threat-related activation in the left posterior cingulate and left middle frontal cortices, but the activation was significantly greater in panic patients. Panic patients also had more right>left asymmetry of activation in the mid-parahippocampal region. The increased responsivity observed in the posterior cingulate and dorsolateral prefrontal cortices is consistent with the hypothesis that panic disorder patients engage in more extensive memory processing of threat-related stimuli. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/12634477) ![Shawn J Kile, M.D.](https://dyn.mktgcdn.com/p/q0wjBudDBEScUW_Fehb6xrCnhqVyTm2ZGn3nY5fkqXc/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Shawn J Kile, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/shawn-j-kile-md-1049681124) ## Research topics - [Neurological Disorders](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Neurological+Disorders%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Neuropsychiatric update: neuroimaging schizophrenia.](https://www.sutterhealth.org/research/publications/neuropsychiatric-update-neuroimaging-1055312750) Psychopharmacol Bull. 2007;40(4):156-67. Neuropsychiatric update: neuroimaging schizophrenia. Kile SJ. Psychopharmacol Bull. 2007;40(4):156-67. Neuropsychiatric update: neuroimaging schizophrenia. Kile SJ. 2007 Jul 20 - Publication ### [New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis](https://www.sutterhealth.org/research/publications/new-sex-specific-migraine-susceptibility-1055312836) Choquet H, Yin J, Jacobson AS, Horton BH, Hoffmann TJ, Jorgenson E, Avins AL, Pressman AR Commun Biol.4(1):864. doi: 10.1038/s42003-021-02356-y. 2021 Jul 22 - Publication ### [Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling.](https://www.sutterhealth.org/research/publications/pharmacodynamic-effects-interferon-beta-1a-ms-1055312290) Kantor AB, Deng J, Waubant E, Lin H, Becker CH, Lacy JR, Perrone AM, Bennett D, Goelz SE. J Neuroimmunol. 188(1-2):103-16. 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Epub 2015 Jun 11. 2016 Apr 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/brainregionsshowingincreasedactivation-1055312756#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Brain regions showing increased activation"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/brainregionsshowingincreasedactivation-1055312756#medicalscholarlyarticle","name":"Brain regions showing increased activation by threat-related words in panic disorder.","headline":"Brain regions showing increased activation","abstract":"Abstract Threat-related stimuli consistently activate the posterior cingulate cortex in normal subjects and have exaggerated effects on memory in patients with panic disorder. 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