--- title: "Diagnostic yield of navigation bronchoscopy with propofol. | Sutter Health" description: "Diagnostic yield of navigation bronchoscopy with propofol." url: "https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Diagnostic yield of navigation bronchoscopy with propofol. # The diagnostic yield of navigational bronchoscopy performed with propofol deep sedation. Mohanasundaram U, Ho LA, Kuschner WG, Chitkara RK, Canfield J, Canfield LM, & Krishna G. _Endoscopy. 2013 (Article ID 824693): 5 pages_ 2013-06-01 ## Abstract Objective. To describe the diagnostic yield of electromagnetic navigation bronchoscopy (ENB) utilizing propofol for procedural deep sedation. Methods. We conducted a structured retrospective analysis of the medical records of patients who underwent ENB with propofol for the evaluation of pulmonary nodules and masses. We analyzed the relationships between lesion size and location, variance (CT-to-body divergence), and positron emission tomography findings on diagnostic yield. Diagnoses were established by histopathological evaluation and clinical-radiographic followup. Results. 41 patients underwent ENB during the study period. The overall diagnostic yield was 89% (42 of 47 target lesions). Among the 42 positive specimens, the diagnoses were squamous cell carcinoma (?? = 10), adenocarcinoma (?? = 14), small cell carcinoma (?? = 2), adenocarcinoma in situ (?? = 2), coccidioidomycosis (?? = 1), and inflammatory processes (?? = 13).Average lesion size was 3.01±0.21 cm and variance 3.6±0.15 mm.Thediagnostic yield was greater when the lesion size was >4 cm (100%) and when variance was ≤4mm (91% versus 87%, ?? = 0.003). Conclusion. The diagnostic yield of ENB utilizing propofol for procedural deep sedation at our center was excellent. ENB with deep sedation may result in superior diagnostic yield compared with ENB performed with moderate sedation. [PubMed abstract](http://www.hindawi.com/journals/isrn/2013/824693/) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Transbronchial cryobiopsy: a new tool for lung biopsies.](https://www.sutterhealth.org/research/publications/transbronchial-cryobiopsy-new-tool-lung-biopsies-1055312940) Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, Hetzel M. Respiration. 78(2):203-8. doi: 10.1159/000203987. 2009 Feb 21 - Publication ### [Minimally invasive techniques for the diagnosis of peripheral pulmonary nodules.](https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945) Krishna G, Gould MK. Curr Opin Pulm Med. 14(4):282-6. doi: 10.1097/MCP.0b013e328303df1b. 2008 Jul 01 - Publication ### [Nivolumab-induced granulomatous inflammation of the pleura.](https://www.sutterhealth.org/research/publications/nivolumab-induced-granulomat-inflammatn-pleura-1055312317) Benn BS, Lombard CM, Krishna G. J Thorac Oncol. 12(7):e100-e101. doi: 10.1016/j.jtho.2017.03.006. 2017 Jul 01 - Publication ### [Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis.](https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931) Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Maria-Malinao M-C, Li Y, Canfield J, Basham B, de Waal Malefyt R, McClanahan T, Krishna G, Fick R Jr. Exp Lung Res. 37(4):227-38. doi: 10.3109/01902148.2010.538132. Epub 2011 Feb 11. 2011 May 01 - Publication ### [Patient dose simulations for scanning-beam digital x-ray tomosynthesis of the lungs.](https://www.sutterhealth.org/research/publications/pt-dose-simulations-sbdx-lung-tomosynthesis-1055312925) Nelson G, Yoon S, Krishna G, Wilfley B, Fahrig R. Med Phys. 40(11):111917. doi: 10.1118/1.4826159. 2013 Nov 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Diagnostic yield of navigation bronchoscopy with propofol."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849#medicalscholarlyarticle","name":"The diagnostic yield of navigational bronchoscopy performed with propofol deep sedation.","headline":"Diagnostic yield of navigation bronchoscopy with propofol.","abstract":"Objective. To describe the diagnostic yield of electromagnetic navigation bronchoscopy (ENB) utilizing propofol for procedural deep sedation. Methods. We conducted a structured retrospective analysis of the medical records of patients who underwent ENB with propofol for the evaluation of pulmonary nodules and masses. We analyzed the relationships between lesion size and location, variance (CT-to-body divergence), and positron emission tomography findings on diagnostic yield. Diagnoses were established by histopathological evaluation and clinical-radiographic followup. Results. 41 patients underwent ENB during the study period. The overall diagnostic yield was 89% (42 of 47 target lesions). Among the 42 positive specimens, the diagnoses were squamous cell carcinoma (?? = 10), adenocarcinoma (?? = 14), small cell carcinoma (?? = 2), adenocarcinoma in situ (?? = 2), coccidioidomycosis (?? = 1), and inflammatory processes (?? = 13).Average lesion size was 3.01±0.21 cm and variance 3.6±0.15 mm.Thediagnostic yield was greater when the lesion size was >4 cm (100%) and when variance was ≤4mm (91% versus 87%, ?? = 0.003). Conclusion. The diagnostic yield of ENB utilizing propofol for procedural deep sedation at our center was excellent. ENB with deep sedation may result in superior diagnostic yield compared with ENB performed with moderate sedation.","description":"Diagnostic yield of navigation bronchoscopy with propofol.","keywords":["Lung Diseases"],"datePublished":"2013-06-01","url":"https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849","inLanguage":"en-US","isPartOf":{"@type":"Periodical","name":"Endoscopy"},"author":[{"@type":"Person","name":"Mohanasundaram U"},{"@type":"Person","name":"Ho LA"},{"@type":"Person","name":"Kuschner WG"},{"@type":"Person","name":"Chitkara RK"},{"@type":"Person","name":"Canfield J"},{"@type":"Person","name":"Canfield LM"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082","name":"Krishna G","url":"https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Lung Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Lung+Diseases%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849#breadcrumblist"}}} ```