--- title: "Endobrachial injection amphotericin B tx aspergilloma. | Sutter Health" description: "This is the first reported tx of aspergilloma (in 71 yo female) with EBUS-guided transbronchial needle injection of liposomal amphotericin B." url: "https://www.sutterhealth.org/research/publications/endobrachial-injection-amphotericin-b-aspergilloma-1055312303" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Endobrachial injection amphotericin B tx aspergilloma. # Endobronchial ultrasound-guided transbronchial needle injection of liposomal amphotericin B for the treatment of symptomatic aspergilloma. Parikh MS, Seeley E, Nguyen-Tran E, & Krishna G. _J Bronchology Interv Pulmonol. doi: 10.1097/LBR.0000000000000383. \[Epub ahead of print\]_ 2017-06-05 ## Abstract Surgical treatment with lung resection has traditionally been the treatment of choice for pulmonary cavities containing aspergillomas that cause hemoptysis. Endobronchial ultrasound (EBUS) is a minimally invasive bronchoscopic technique that is commonly used for transbronchial needle aspiration of hilar and mediastinal lymph nodes as well as centrally located parenchymal lesions. Here, we describe a case of a 71-year-old woman who was found to have a cavitary lesion in the lung containing aspergillomas. Under direct ultrasound visualization with EBUS, liposomal amphotericin B was injected into the aspergillomas. These aspergillomas regressed after treatment. To our knowledge, this is the first reported treatment of aspergilloma with EBUS-guided transbronchial needle injection of liposomal amphotericin B. [PubMed abstract](https://www.ncbi.nlm.nih.gov/pubmed/28590275) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Update on the treatment of lymphangioleiomyomatosis.](https://www.sutterhealth.org/research/publications/update-treatment-lymphangioleiomyomatosis-1055312862) Krishna G, Berry G, Kao P, Rosen G, Raffin TA. Clin Pulmon Med. 6(2):126-132. 1999 Mar 01 - Publication ### [PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.](https://www.sutterhealth.org/research/publications/pg490-88-blocks-bleomycin-induced-lung-fibrosis-1055312795) Krishna G, Liu K, Shigemitsu H, Gao M, Raffin TA, Rosen GD. Am J Pathol. 158(3):997-1004. 2001 Mar 01 - Publication ### [A 24-year-old woman with bilateral pulmonary infiltrates, pericardial effusion, and bilateral pleural effusions.](https://www.sutterhealth.org/research/publications/24-yo-woman-pulmonary-infiltrates-effusions-1055312831) Katikireddy CK, Krishna G, Berry G, Faul J, Kuschner W. Chest. 128(6):4013-7. 2005 Dec 01 - Publication ### [The dying thoracic patient.](https://www.sutterhealth.org/research/publications/dying-thoracic-patient-1055312967) Krishna G, Raffin TA. Chest Surg Clin N Am. 8(3):723-39. 1998 Aug 01 - Publication ### [A multicenter RCT of Zephyr® Endobronchial Valve treatment in heterogeneous emphysema (LIBERATE).](https://www.sutterhealth.org/research/publications/rct-zephyr-endobronchial-valve-tx-emphysema-liberate-1055312389) Criner GJ, Sue R, Wright S, Dransfield M, Rivas-Perez H, Wiese T, Sciurba FC, Shah PL, Wahidi MM, de Oliveira HG, Morrissey B, Cardoso PFG, Hays S, Majid A, Pastis N Jr, Kopas L, Vollenweider M, McFadden PM, Machuzak M, Hsia DW, Sung A, Jarad N, Kornaszewska M, Hazelrigg S, Krishna G, Armstrong B, Shargill NS, Slebos DJ; LIBERATE Study Group. Am J Respir Crit Care Med. doi: 10.1164/rccm.201803-0590OC. \[Epub ahead of print\] 2018 May 22 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/endobrachial-injection-amphotericin-b-aspergilloma-1055312303#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Endobrachial injection amphotericin B tx aspergilloma."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/endobrachial-injection-amphotericin-b-aspergilloma-1055312303#medicalscholarlyarticle","name":"Endobronchial ultrasound-guided transbronchial needle injection of liposomal amphotericin B for the treatment of symptomatic aspergilloma.","headline":"Endobrachial injection amphotericin B tx aspergilloma.","abstract":"Surgical treatment with lung resection has traditionally been the treatment of choice for pulmonary cavities containing aspergillomas that cause hemoptysis. Endobronchial ultrasound (EBUS) is a minimally invasive bronchoscopic technique that is commonly used for transbronchial needle aspiration of hilar and mediastinal lymph nodes as well as centrally located parenchymal lesions. Here, we describe a case of a 71-year-old woman who was found to have a cavitary lesion in the lung containing aspergillomas. Under direct ultrasound visualization with EBUS, liposomal amphotericin B was injected into the aspergillomas. These aspergillomas regressed after treatment. 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