--- title: "Potential hazards of submucosal injection of methylene blue. | Sutter Health" description: "Endoscopists have routinely used submucosal injection of diluted methylene blue or indigo carmine to enhance the safety and ensure the completeness of colonoscopic resection of large, sessile polyps. Both dyes are similarly colored blue, yet important features differentiate the two." url: "https://www.sutterhealth.org/research/publications/hazards-submucosal-injection-methylene-blue-1055312987" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Potential hazards of submucosal injection of methylene blue. # Potential hazards of submucosal injection of methylene blue. Chan EP, Kaltenbach T, Rouse RV, & Soetikno R. _Am J Gastroenterol. 107(4):633-4. doi: 10.1038/ajg.2011.462._ 2012-04-01 ## Abstract Endoscopists have routinely used submucosal injection of diluted methylene blue or indigo carmine to enhance the safety and ensure the completeness of colonoscopic resection of large, sessile polyps. Both dyes are similarly colored blue, yet important features differentiate the two. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/22475968) ## Research topics - [Digestive Disorders](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Digestive+Disorders%5C%22%22) - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Chemoprevention: risk reduction with medical therapy of inflammatory bowel disease.](https://www.sutterhealth.org/research/publications/crc-risk-reduction-med-therapy-ibd-1055312878) Chan EP, Lichtenstein GR. 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J Foot Ankle Surg. pii: S1067-2516(16)30393-3. doi: 10.1053/j.jfas.2016.11.012. \[Epub ahead of print\] 2017 Jan 12 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/hazards-submucosal-injection-methylene-blue-1055312987#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Potential hazards of submucosal injection of methylene blue."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/hazards-submucosal-injection-methylene-blue-1055312987#medicalscholarlyarticle","name":"Potential hazards of submucosal injection of methylene blue.","headline":"Potential hazards of submucosal injection of methylene blue.","abstract":"Endoscopists have routinely used submucosal injection of diluted methylene blue or indigo carmine to enhance the safety and ensure the completeness of colonoscopic resection of large, sessile polyps. 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