--- title: "High-resolution variable-density 3D cones coronary MRA. | Sutter Health" description: "Coronary MR angiography with isotropic submillimeter spatial resolution and high temporal resolution can be performed with VD 3D cones to improve the depiction of coronary arteries." url: "https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. High-resolution variable-density 3D cones coronary MRA. # High-resolution variable-density 3D cones coronary MRA. Addy NO, Ingle RR, Wu HH, Hu BS, & Nishimura DG. _Magn Reson Med. 74(3):614-21. doi: 10.1002/mrm.25803. Epub 2015 Jul 14._ 2015-09-01 ## Abstract PURPOSE: To improve the spatial/temporal resolution of whole-heart coronary MR angiography by developing a variable-density (VD) 3D cones acquisition suitable for image reconstruction with parallel imaging and compressed sensing techniques. METHODS: A VD 3D cones trajectory design incorporates both radial and spiral trajectory undersampling techniques to achieve higher resolution. This design is used to generate a VD 3D cones trajectory with 0.8 mm/66 ms isotropic spatial/temporal resolution, using a similar number of readouts as our previous fully sampled cones trajectory (1.2 mm/100 ms). Scans of volunteers and patients are performed to evaluate the performance of the VD trajectory, using non-Cartesian L1 -ESPIRiT for high-resolution image reconstruction. RESULTS: With gridding reconstruction, the high-resolution scans experience an expected drop in signal-to-noise and contrast-to-noise ratios, but with L1 -ESPIRiT, the apparent noise is substantially reduced. Compared with 1.2 mm images, in each volunteer, the L1 -ESPIRiT 0.8 mm images exhibit higher vessel sharpness values in the right and left anterior descending arteries. CONCLUSION: Coronary MR angiography with isotropic submillimeter spatial resolution and high temporal resolution can be performed with VD 3D cones to improve the depiction of coronary arteries. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/26172829) ![Bob S Hu, M.D.](https://dyn.mktgcdn.com/p/OLtyV-80yDbOmh0GcQI3xnNzxEtgLP1RmJcZvvKP3u4/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Bob S Hu, M.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033) ## Research topics - [Cardiovascular Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Cardiovascular+Diseases%5C%22%22) - [Disease Management](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Disease+Management%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Effect of financial incentives to physicians, patients, or both on lipid levels: a randomized clinical trial.](https://www.sutterhealth.org/research/publications/financial-md-and-pt-incentives-on-lipid-levels-1055312784) Asch DA, Troxel AB, Stewart WF, Sequist TD, Jones JB, Hirsch AG, Hoffer K, Zhu J, Wang W, Hodlofski A, Frasch AB, Weiner MG, Finnerty DD, Rosenthal MB, Gangemi K, Volpp KG. JAMA. 314(18):1926-35. doi: 10.1001/jama.2015.14850. 2015 Nov 10 - Publication ### [Cardiovascular magnetic resonance phase contrast imaging.](https://www.sutterhealth.org/research/publications/cardiovasc-mri-phase-contrast-1055312458) Nayak KS, Nielsen JF, Bernstein MA, Markl M, D Gatehouse P, M Botnar R, Saloner D, Lorenz C, Wen H, S Hu B, Epstein FH, N Oshinski J, Raman SV. J Cardiovasc Magn Reson. 17(1):71. doi: 10.1186/s12968-015-0172-7. 2015 Aug 09 - Publication ### [Nonrigid motion correction with 3D image-based navigators for coronary MR angiography.](https://www.sutterhealth.org/research/publications/motion-correction-3d-image-navig-ht-mra-1055312449) Luo J, Addy NO, Ingle RR, Baron CA, Cheng JY, Hu BS, Nishimura DG. Magn Reson Med. doi: 10.1002/mrm.26273. \[Epub ahead of print\] 2016 May 13 - Publication ### [3D image-based navigators for coronary MR angiography.](https://www.sutterhealth.org/research/publications/3d-image-navig-ht-mr-angiography-1055312459) Addy NO, Ingle RR, Luo J, Baron CA, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. doi: 10.1002/mrm.26269. \[Epub ahead of print\] 2016 May 13 - Publication ### [Rapid single-breath-hold 3D late gadolinium enhancement cardiac MRI using a stack-of-spirals acquisition.](https://www.sutterhealth.org/research/publications/rapid-3d-gadolinium-enhancemt-cardiac-mri-1055312461) Shin T, Lustig M, Nishimura DG, Hu BS. J Magn Reson Imaging. 40(6):1496-502. doi: 10.1002/jmri.24494. Epub 2013 Nov 15. J Magn Reson Imaging. 40(6):1496-502. doi: 10.1002/jmri.24494. Epub 2013 Nov 15. Send to: 2014 Dec 02 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"High-resolution variable-density 3D cones coronary MRA."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425#medicalscholarlyarticle","name":"High-resolution variable-density 3D cones coronary MRA.","headline":"High-resolution variable-density 3D cones coronary MRA.","abstract":"PURPOSE: To improve the spatial/temporal resolution of whole-heart coronary MR angiography by developing a variable-density (VD) 3D cones acquisition suitable for image reconstruction with parallel imaging and compressed sensing techniques. METHODS: A VD 3D cones trajectory design incorporates both radial and spiral trajectory undersampling techniques to achieve higher resolution. This design is used to generate a VD 3D cones trajectory with 0.8 mm/66 ms isotropic spatial/temporal resolution, using a similar number of readouts as our previous fully sampled cones trajectory (1.2 mm/100 ms). Scans of volunteers and patients are performed to evaluate the performance of the VD trajectory, using non-Cartesian L1 -ESPIRiT for high-resolution image reconstruction. RESULTS: With gridding reconstruction, the high-resolution scans experience an expected drop in signal-to-noise and contrast-to-noise ratios, but with L1 -ESPIRiT, the apparent noise is substantially reduced. Compared with 1.2 mm images, in each volunteer, the L1 -ESPIRiT 0.8 mm images exhibit higher vessel sharpness values in the right and left anterior descending arteries. CONCLUSION: Coronary MR angiography with isotropic submillimeter spatial resolution and high temporal resolution can be performed with VD 3D cones to improve the depiction of coronary arteries.","description":"Coronary MR angiography with isotropic submillimeter spatial resolution and high temporal resolution can be performed with VD 3D cones to improve the depiction of coronary arteries.","keywords":["Cardiovascular Diseases","Disease Management"],"datePublished":"2015-09-01","url":"https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"26172829"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1002/mrm.25803"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/26172829/","https://doi.org/10.1002/mrm.25803"],"isPartOf":{"@type":"Periodical","name":"Magn Reson Med"},"author":[{"@type":"Person","name":"Addy NO"},{"@type":"Person","name":"Ingle RR"},{"@type":"Person","name":"Wu HH"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033","name":"Hu BS","url":"https://www.sutterhealth.org/research/investigators/bob-s-hu-md-1049681033"},{"@type":"Person","name":"Nishimura DG"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Cardiovascular Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Cardiovascular+Diseases%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Disease Management","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Disease+Management%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/high-resolution-vary-density-3d-cones-coronary-mra-1055312425#breadcrumblist"}}} ```