--- title: "Hyperlocalized Measures of Air Pollution and Preeclampsia | Sutter Health" description: "Exposure to nitrogen dioxide (NO2), black carbon (BC), and ultrafine particles (UFPs) during pregnancy may increase the risk of preeclampsia" url: "https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Hyperlocalized Measures of Air Pollution and Preeclampsia # Hyperlocalized Measures of Air Pollution and Preeclampsia in Oakland, California Goin DE, Sudat S, Riddell C, Morello-Frosch R, Apte JS, Glymour MM, Karasek D, & Casey JA _Environ Sci Technol. doi: 10.1021/acs.est.1c02151. Online ahead of print._ 2021-10-14 ## Abstract ****Abstract**** Exposure to nitrogen dioxide (NO2), black carbon (BC), and ultrafine particles (UFPs) during pregnancy may increase the risk of preeclampsia, but previous studies have not assessed hyper localized differences in pollutant levels, which may cause exposure misclassification. We used data from Google Street View cars with mobile air monitors that repeatedly sampled NO2, BC, and UFPs every 30 m in Downtown and West Oakland neighborhoods during 2015-2017. Data were linked to electronic health records of pregnant women in the 2014-2016 Sutter Health population, who resided within 120 m of monitoring data (N = 1095), to identify preeclampsia cases. We used G-computation with log-binomial regression to estimate risk differences (RDs) associated with a hypothetical intervention reducing pollutant levels to the 25th percentile observed in our sample on preeclampsia risk, overall and stratified by race/ethnicity. Prevalence of preeclampsia was 6.8%. Median (interquartile range) levels of NO2, BC, and UFPs were 10.8 ppb (9.0, 13.0), 0.34 μg/m3 (0.27, 0.42), and 29.2 # × 103/cm3 (26.6, 32.6), respectively. Changes in the risk of preeclampsia achievable by limiting each pollutant to the 25th percentile were NO2 RD = -1.5 per 100 women (95% confidence interval (CI): -2.5, -0.5); BC RD = -1.0 (95% CI: -2.2, 0.02); and UFP RD = -0.5 (95% CI: -1.8, 0.7). Estimated effects were the largest for non-Latina Black mothers: NO2 RD = -2.8 (95% CI: -5.2, -0.3) and BC RD = -3.0 (95% CI: -6.4, 0.4). [PubMed abstract](https://pubmed.ncbi.nlm.nih.gov/34648281/) ![Sylvia Sudat, Ph.D.](https://dyn.mktgcdn.com/p/2AHRaDJwevdbwzC2ecrwY3nYIxbiqxd9NbpxBlI8Kpk/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Sylvia Sudat, Ph.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/sylvia-sudat-phd-1049681027) ## Research topics - [Environmental Exposure](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Environmental+Exposure%5C%22%22) - [Health Disparities](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Health+Disparities%5C%22%22) - [Maternal and Infant Health](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Maternal+and+Infant+Health%5C%22%22) - [Women's Health](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Women%27s+Health%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Physician mothers' experience of workplace discrimination: a qualitative analysis.](https://www.sutterhealth.org/research/publications/md-mothers-and-workplace-discrimination-1055312433) Halley MC, Rustagi AS, Torres JS, Linos E, Plaut V, Mangurian C, Choo E, Linos E. BMJ. 363:k4926. doi: 10.1136/bmj.k4926. 2018 Dec 12 - Publication ### [Women’s out-of-pocket expenditures and dispensing patterns for oral contraceptive pills between 1996 and 2006.](https://www.sutterhealth.org/research/publications/oop-costs-dispensing-for-oral-contraceptives-1055312599) Liang SY, Grossman D, Phillips KA. Contraception. 83(6):528-36. doi: 10.1016/j.contraception.2010.09.013 2011 Jun 01 - Publication ### [Genomic testing & therapies for breast cancer in clinical practice.](https://www.sutterhealth.org/research/publications/genomic-testing-therapies-for-breast-cancer-1055312617) Haas JS, Phillips KA, Liang SY, Hassett MJ, Keohane C, Elkin EB, Armstrong J, Toscano M. 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Am J Hypertension. pii: hpu189. \[Epub ahead of print\] 2014 Oct 28 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Hyperlocalized Measures of Air Pollution and Preeclampsia"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858#medicalscholarlyarticle","name":"Hyperlocalized Measures of Air Pollution and Preeclampsia in Oakland, California","headline":"Hyperlocalized Measures of Air Pollution and Preeclampsia","abstract":"Abstract Exposure to nitrogen dioxide (NO2), black carbon (BC), and ultrafine particles (UFPs) during pregnancy may increase the risk of preeclampsia, but previous studies have not assessed hyper localized differences in pollutant levels, which may cause exposure misclassification. We used data from Google Street View cars with mobile air monitors that repeatedly sampled NO2, BC, and UFPs every 30 m in Downtown and West Oakland neighborhoods during 2015-2017. Data were linked to electronic health records of pregnant women in the 2014-2016 Sutter Health population, who resided within 120 m of monitoring data (N = 1095), to identify preeclampsia cases. We used G-computation with log-binomial regression to estimate risk differences (RDs) associated with a hypothetical intervention reducing pollutant levels to the 25th percentile observed in our sample on preeclampsia risk, overall and stratified by race/ethnicity. Prevalence of preeclampsia was 6.8%. Median (interquartile range) levels of NO2, BC, and UFPs were 10.8 ppb (9.0, 13.0), 0.34 μg/m3 (0.27, 0.42), and 29.2 # × 103/cm3 (26.6, 32.6), respectively. Changes in the risk of preeclampsia achievable by limiting each pollutant to the 25th percentile were NO2 RD = -1.5 per 100 women (95% confidence interval (CI): -2.5, -0.5); BC RD = -1.0 (95% CI: -2.2, 0.02); and UFP RD = -0.5 (95% CI: -1.8, 0.7). Estimated effects were the largest for non-Latina Black mothers: NO2 RD = -2.8 (95% CI: -5.2, -0.3) and BC RD = -3.0 (95% CI: -6.4, 0.4).","description":"Exposure to nitrogen dioxide (NO2), black carbon (BC), and ultrafine particles (UFPs) during pregnancy may increase the risk of preeclampsia","keywords":["Environmental Exposure","Health Disparities","Maternal and Infant Health","Women's Health"],"datePublished":"2021-10-14","url":"https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"PMID","value":"34648281"},{"@type":"PropertyValue","propertyID":"DOI","value":"10.1021/acs.est.1c02151"}],"sameAs":["https://pubmed.ncbi.nlm.nih.gov/34648281/","https://doi.org/10.1021/acs.est.1c02151"],"isPartOf":{"@type":"Periodical","name":"Environ Sci Technol"},"author":[{"@type":"Person","name":"Goin DE"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/sylvia-sudat-phd-1049681027","name":"Sudat S","url":"https://www.sutterhealth.org/research/investigators/sylvia-sudat-phd-1049681027"},{"@type":"Person","name":"Riddell C"},{"@type":"Person","name":"Morello-Frosch R"},{"@type":"Person","name":"Apte JS"},{"@type":"Person","name":"Glymour MM"},{"@type":"Person","name":"Karasek D"},{"@type":"Person","name":"Casey JA"}],"about":[{"@type":"DefinedTerm","name":"Environmental Exposure","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Environmental+Exposure%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Health Disparities","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Health+Disparities%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Maternal and Infant Health","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Maternal+and+Infant+Health%22%5D%7D%5D&verticalKey=research_publication"},{"@type":"DefinedTerm","name":"Women's Health","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Women%27s+Health%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/hyperlocalized-measures-of-air-pollution-preeclampsia-1055312858#breadcrumblist"}}} ```