--- title: "influence of comorbidity triple-negative breast cancer | Sutter Health" description: "The influence of comorbidity on treatment and survival of triple-negative breast cancer" url: "https://www.sutterhealth.org/research/publications/influence-of-comorbidity-triple-negative-breast-cancer-1055312682" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. influence of comorbidity triple-negative breast cancer # The influence of comorbidity on treatment and survival of triple-negative breast cancer _The Breast Journal_ 2020-09-26 ## Abstract Concomitant comorbidity is a key factor in treatment decision-making for breast cancer. The aim of this study was to determine how the Charlson Comorbidity Index (CCI) affected treatment and risk of mortality of women with TNBC, the subtype with the poorest prognosis. We accessed 20 177 cases of TNBC from the California Cancer Registry 2000-2015 with documented Charlson Comorbidity Index (CCI). Cox Regression was used to compute the adjusted risk of breast cancer-specific mortality for a CCI of 1 (low comorbidity) and 2+ (high comorbidity) vs a CCI of 0 (no comorbidity). Logistic regression was used to compute the association of CCI with treatment of mastectomy, lumpectomy + radiation, and chemotherapy. Analyses were conducted separately for each stage. Patients with high comorbidity CCI (2+) were less likely to receive systemic chemotherapy irrespective of Stage. High comorbidity was associated with higher breast-specific mortality in all stages of disease. High comorbidity did not have an effect on the use of lumpectomy and radiation of stage 1 breast cancer but was associated with reduced use in stages 2-4. Comorbidity was not associated with decreased risk of mastectomy except for patients with high comorbidity in stage 3. Concomitant comorbidity influences treatment decisions and breast cancer-specific mortality in patients with TNBC. [PubMed abstract](https://doi.org/10.1111/tbj.13924) ![Carol Parise, Ph.D.](https://www.sutterhealth.org/static/images/sutter-fallback-image-3-4.jpg) Carol Parise, Ph.D. Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/carol-parise-phd-1049681206) ## Research topics - [Breast Cancer](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Breast+Cancer%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [The Unmet Needs of Breast Cancer Navigation Services: Reconciling Clinical Care With the Emotional and Logistical Challenges Experienced by Younger Women with Breast Cancer in a Healthcare Delivery System](https://www.sutterhealth.org/research/publications/unmet-needs-of-breast-cancer-navigation-services-1055312880) Journal of Patient Experience 2023 Jun 04 - Publication ### [The association of race/ethnicity in male breast cancer survival within similar comorbidity cohorts](https://www.sutterhealth.org/research/publications/association-of-raceethnicity-in-male-breast-cancer-survival-1055312670) Cancer 2023 Mar 01 - Publication ### [Does the diagnosis of breast or ovarian cancer trigger referral to genetic counseling?](https://www.sutterhealth.org/research/publications/breast-ovarian-cancer-dx-trigger-genetic-counseling-referral-1055312651) Powell CB, Littell R, Hoodfar E, Sinclair F, Pressman A. Int J Gynecol Cancer. 23(3):431-6. doi: 10.1097/IGC.0b013e318280f2b4. 2013 Mar 01 - Publication ### [Adiposity, inflammation, genetic variants and risk of post-menopausal breast cancer findings from a prospective-specimen-collection, retrospective-blinded-evaluation (PRoBE) design approach.](https://www.sutterhealth.org/research/publications/adiposity-inflammation-gene-variants-breast-cancer-risk-1055312676) Yan XS, Barnholtz-Sloan J, Chu X, Li L, Colonie R, Webster J, Smelser D, Patel N, Prichard J, Stark A. Springerplus. 2:638. doi: 10.1186/2193-1801-2-638. eCollection 2013. 2013 Nov 27 - Publication ### [Breast cancer chemoprevention in primary care - assessing readiness for change.](https://www.sutterhealth.org/research/publications/breast-cancer-chemoprevention-in-primary-care-1055312742) Wang H, Snyder CF, Larson S, Vogel V, Kirchner HL, Sun H, Yan X. 24(6):283-288. Qual Prim Care. 2016 Nov 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/influence-of-comorbidity-triple-negative-breast-cancer-1055312682#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"influence of comorbidity triple-negative breast cancer"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/influence-of-comorbidity-triple-negative-breast-cancer-1055312682#medicalscholarlyarticle","name":"The influence of comorbidity on treatment and survival of triple-negative breast cancer","headline":"influence of comorbidity triple-negative breast cancer","abstract":"Concomitant comorbidity is a key factor in treatment decision-making for breast cancer. The aim of this study was to determine how the Charlson Comorbidity Index (CCI) affected treatment and risk of mortality of women with TNBC, the subtype with the poorest prognosis. We accessed 20 177 cases of TNBC from the California Cancer Registry 2000-2015 with documented Charlson Comorbidity Index (CCI). Cox Regression was used to compute the adjusted risk of breast cancer-specific mortality for a CCI of 1 (low comorbidity) and 2+ (high comorbidity) vs a CCI of 0 (no comorbidity). Logistic regression was used to compute the association of CCI with treatment of mastectomy, lumpectomy + radiation, and chemotherapy. Analyses were conducted separately for each stage. Patients with high comorbidity CCI (2+) were less likely to receive systemic chemotherapy irrespective of Stage. High comorbidity was associated with higher breast-specific mortality in all stages of disease. High comorbidity did not have an effect on the use of lumpectomy and radiation of stage 1 breast cancer but was associated with reduced use in stages 2-4. Comorbidity was not associated with decreased risk of mastectomy except for patients with high comorbidity in stage 3. 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