--- title: "Mediators of asthma outcomes | Sutter Health" description: "Patient adherence, the level of asthma self-management skills, stress exposure, & depression can have considerable influence on a wide range of asthma outcomes." url: "https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Mediators of asthma outcomes # Mediators of asthma outcomes Rand CS, Wright RJ, Cabana MD, Foggs MB, Halterman JS, Olson L, Vollmer WM, Wilson SR, & Taggart V. _J Allergy Clin Immunol. 129(3 Suppl):S136-41._ 2012-03-01 ## Abstract ****Background**** Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. ****Objective**** National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. ****Methods**** We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. ****Results**** The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. ****Conclusions**** Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions. [PubMed abstract](http://www.jacionline.org/article/S0091-6749\(11\)02956-3/abstract) ## Research topics - [Asthma](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Asthma%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Secondhand tobacco smoke in children with asthma: sources of and parental perceptions about exposure in children and parental readiness to change.](https://www.sutterhealth.org/research/publications/parents-smoking-and-children-with-asthma-1055312631) Farber HJ, Knowles SB, Brown NL, Caine L, Luna V, Qian Y, Lavori P, Wilson SR. Chest. 133(6):1367-74. doi: 10.1378/chest.07-2369. Epub 2008 Mar 13. 2008 Jun 01 - Publication ### [Asthma outcomes: Quality of life](https://www.sutterhealth.org/research/publications/asthma-outcomes-quality-of-life-1055312634) Wilson SR, Rand CS, Cabana MD, Foggs MB, Halterman JS, Olson L, Vollmer WM, Wright RJ, Taggart V J Allergy Clin Immunol. 129:S88-123. (e-published March 1 2012). Doi: 10.1016/j.jaci.2011.12.988) 2012 Mar 01 - Publication ### [Shared treatment decision making improves adherence and outcomes in poorly controlled asthma.](https://www.sutterhealth.org/research/publications/shared-decision-making-improves-asthma-outcomes-1055312698) Wilson SR, Strub P, Buist AS, Knowles SB, Lavori PW, Lapidus J, Vollmer WM; Better Outcomes of Asthma Treatment (BOAT) Study Group. Am J Respir Crit Care Med. 181(6):566-77. doi: 10.1164/rccm.200906-0907OC. Epub 2009 Dec 17. 2010 Mar 15 - Publication ### [A new measure to assess asthma's impact on quality of life from the patient's perspective.](https://www.sutterhealth.org/research/publications/assess-qol-in-asthma-pt-point-of-view-1055312418) Wilson SR, Mulligan MJ, Ayala E, Chausow A, Huang Q, Knowles SB, Gummidipundi S, Castro M, Wise RA. J Allergy Clin Immunol. pii: S0091-6749(17)30887-4. doi: 10.1016/j.jaci.2017.02.047. \[Epub ahead of print\] 2017 Jun 01 - Publication ### [Performance of the Asthma Impact on Quality of Life Scale (A-IQOLS) in diverse asthma research populations and demographic sub-groups.](https://www.sutterhealth.org/research/publications/asthma-impact-on-quality-of-life-scale-performance-in-pops-1055312339) Wilson SR, Wise RA, Castro M, Mulligan MJ, Ayala E, Chausow A, Huang Q, Gummidipundi S. J Allergy Clin Immunol. pii: S0091-6749(18)30634-1. doi: 10.1016/j.jaci.2018.02.056. \[Epub ahead of print\] 2018 May 03 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Mediators of asthma outcomes"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653#medicalscholarlyarticle","name":"Mediators of asthma outcomes","headline":"Mediators of asthma outcomes","abstract":"Background Patient adherence, the level of asthma self-management skills, exposure to stress, and depression can have considerable influence on a wide range of asthma outcomes and thus are considered asthma outcome mediators. Objective National Institutes of Health institutes and other federal agencies convened an expert group to recommend standardized measures for 7 domains of asthma clinical research outcomes measures. Although the review of mediators of these outcomes was not within the scope of any specific outcome topic, a brief summary is presented so that researchers might consider potential mediators. Methods We prepared a summary of key mediators of asthma outcomes based on expertise and knowledge of the literature. Results The rationale for including measures of adherence, self-management skills, and exposures to stress in asthma clinical research is presented, along with a brief review of instruments for collecting this information from clinical research participants. Conclusions Appropriate measurement of adherence, self-management skills, and exposures to stress will enhance characterization of study participants and provide information about the potential impact these factors can have on mediating the effects of treatment interventions.","description":"Patient adherence, the level of asthma self-management skills, stress exposure, & depression can have considerable influence on a wide range of asthma outcomes.","keywords":["Asthma"],"datePublished":"2012-03-01","url":"https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653","inLanguage":"en-US","isPartOf":{"@type":"Periodical","name":"J Allergy Clin Immunol"},"author":[{"@type":"Person","name":"Rand CS"},{"@type":"Person","name":"Wright RJ"},{"@type":"Person","name":"Cabana MD"},{"@type":"Person","name":"Foggs MB"},{"@type":"Person","name":"Halterman JS"},{"@type":"Person","name":"Olson L"},{"@type":"Person","name":"Vollmer WM"},{"@type":"Person","name":"Wilson SR"},{"@type":"Person","name":"Taggart V"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Asthma","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Asthma%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/mediators-of-asthma-outcomes-1055312653#breadcrumblist"}}} ```