--- title: "Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands. | Sutter Health" description: "Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands." url: "https://www.sutterhealth.org/research/publications/meta-analysis-in-asymmetric-catalysis-influence-o-1055312709" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands. # Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands. Org Biomol Chem. 2013 Jul 28;11(28):4591-601. doi: 10.1039/c3ob40360b. Epub 2013 May 2. Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands. Carroll MP1, Guiry PJ, Brown JM. Author information 1School of Chemistry and Chemical Biology, Centre for Synthesis and Chemical Biology, University College Dublin, Dublin 4, & Ireland. _Org Biomol Chem. 2013 Jul 28;11(28):4591-601. doi: 10.1039/c3ob40360b. Epub 2013 May 2. Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands. Carroll MP1_ _Guiry PJ_ _Brown JM. Author information 1School of Chemistry and Chemical Biology_ _Centre for Synthesis and Chemical Biology_ _University College Dublin_ _Dublin 4_ _Ireland._ 2013-07-28 ## Abstract All X-ray structures of PN ligands forming 6-ring metal complex chelates have been retrieved from the CDS database, and those lacking chelate chirality filtered out. Many of the remainder fit naturally into four main families (PPFA, FcPhox, Phox and Quinap), which have been widely applied to asymmetric catalysis in diverse ways. It is known through experimental observation that certain of these ligand structures are more effective for specific classes of reaction but there has been little by way of explanation for their divergent behaviour. In this paper we examine the wide variation of conformations within individual families of PN complexes in the solid state, establish common features, and make cross-correlations with their effectiveness in specific catalytic asymmetric reactions. The extent of rigidity in the chelate varies widely and yet flexible complexes may be extremely effective in asymmetric catalysis. These observations emphasise the importance of induced fit between reactants and catalyst and militate against over-reliance on rigid lock-and-key models. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/?term=MP+Carroll%2C+meta-analysis+in+asymmetric+catalysis) ## Research topics - [All Cancer](https://www.sutterhealth.org/research-search-results?query=%22%5C%22All+Cancer%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Breast Cancer Subtypes as Defined by the Estrogen Receptor (ER), Progesterone Receptor (PR), and the Human Epidermal Growth Factor Receptor 2 (HER2) among Women with Invasive Breast Cancer in California](https://www.sutterhealth.org/research/publications/breast-cancer-subtypes-as-defined-by-the-estrogen-1055312635) 1999-2004. Breast J. November/December 2009;15(6):593-602. 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Influence of chelate geometry on the roles of PN chelating ligands."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/meta-analysis-in-asymmetric-catalysis-influence-o-1055312709#medicalscholarlyarticle","name":"Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands.","headline":"Meta-analysis in asymmetric catalysis. Influence of chelate geometry on the roles of PN chelating ligands.","abstract":"All X-ray structures of PN ligands forming 6-ring metal complex chelates have been retrieved from the CDS database, and those lacking chelate chirality filtered out. Many of the remainder fit naturally into four main families (PPFA, FcPhox, Phox and Quinap), which have been widely applied to asymmetric catalysis in diverse ways. 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