--- title: "Minimally invasive techniques: peripheral pulmonary nodules | Sutter Health" description: "Transthoracic biopsy may be particularly helpful when an infectious cause is suspected, pt is a marginal candidate for surgery, or malignancy proof is desired." url: "https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Minimally invasive techniques: peripheral pulmonary nodules # Minimally invasive techniques for the diagnosis of peripheral pulmonary nodules. Krishna G & Gould MK. _Curr Opin Pulm Med. 14(4):282-6. doi: 10.1097/MCP.0b013e328303df1b._ 2008-07-01 ## Abstract PURPOSE OF REVIEW: Evaluation and management of patients with pulmonary nodules continue to be a significant clinical challenge due to the possibility of malignancy. RECENT FINDINGS: With advances in technology, several minimally invasive diagnostic options are available for diagnosis of peripheral pulmonary lesions. Development and refinement of minimally invasive sampling techniques will aid in clinical decision making, as well as help advance scientific understanding of lung cancer growth and metastasis. SUMMARY: Although most surgical candidates should be referred promptly for resection, transthoracic or bronchoscopic biopsy may be particularly helpful when an infectious cause is suspected, when the patient is a marginal or poor candidate for surgery, or when a surgical candidate desires proof of malignancy before proceeding to surgery. Newer minimally invasive techniques should be rigorously evaluated for their role in the diagnostic algorithm of peripheral lung lesions. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/?term=Krishna+G%2C+Gould+MK.) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis.](https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931) Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Maria-Malinao M-C, Li Y, Canfield J, Basham B, de Waal Malefyt R, McClanahan T, Krishna G, Fick R Jr. Exp Lung Res. 37(4):227-38. doi: 10.3109/01902148.2010.538132. Epub 2011 Feb 11. 2011 May 01 - Publication ### [Transbronchial cryobiopsy: a new tool for lung biopsies.](https://www.sutterhealth.org/research/publications/transbronchial-cryobiopsy-new-tool-lung-biopsies-1055312940) Babiak A, Hetzel J, Krishna G, Fritz P, Moeller P, Balli T, Hetzel M. Respiration. 78(2):203-8. doi: 10.1159/000203987. 2009 Feb 21 - Publication ### [Nivolumab-induced granulomatous inflammation of the pleura.](https://www.sutterhealth.org/research/publications/nivolumab-induced-granulomat-inflammatn-pleura-1055312317) Benn BS, Lombard CM, Krishna G. J Thorac Oncol. 12(7):e100-e101. doi: 10.1016/j.jtho.2017.03.006. 2017 Jul 01 - Publication ### [The diagnostic yield of navigational bronchoscopy performed with propofol deep sedation.](https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849) Mohanasundaram U, Ho LA, Kuschner WG, Chitkara RK, Canfield J, Canfield LM, Krishna G. Endoscopy. 2013 (Article ID 824693): 5 pages 2013 Jun 01 - Publication ### [Development of the ATAQ-IPF: A tool to assess quality of life in IPF](https://www.sutterhealth.org/research/publications/development-of-the-ataq-ipf-quality-of-life-1055312581) Swigris JJ, Wilson SR, Green KE, Sprunger DB, Brown KK, Wamboldt FS Health Qual Life Outcomes. 8:77. doi: 10.1186/1477-7525-8-77. 2010 Jul 31 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Minimally invasive techniques: peripheral pulmonary nodules"}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945#medicalscholarlyarticle","name":"Minimally invasive techniques for the diagnosis of peripheral pulmonary nodules.","headline":"Minimally invasive techniques: peripheral pulmonary nodules","abstract":"PURPOSE OF REVIEW: Evaluation and management of patients with pulmonary nodules continue to be a significant clinical challenge due to the possibility of malignancy. RECENT FINDINGS: With advances in technology, several minimally invasive diagnostic options are available for diagnosis of peripheral pulmonary lesions. Development and refinement of minimally invasive sampling techniques will aid in clinical decision making, as well as help advance scientific understanding of lung cancer growth and metastasis. SUMMARY: Although most surgical candidates should be referred promptly for resection, transthoracic or bronchoscopic biopsy may be particularly helpful when an infectious cause is suspected, when the patient is a marginal or poor candidate for surgery, or when a surgical candidate desires proof of malignancy before proceeding to surgery. 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