--- title: "Minimran: online system to implement minimization in RCT. | Sutter Health" description: "Have developed a robust, flexible, and readily accessible Web-based treatment allocation system, MinimRan (http://studies.pamfri.org:8080/minimRan/index.jsp)." url: "https://www.sutterhealth.org/research/publications/minimran-online-do-minimization-rct-1055312971" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Minimran: online system to implement minimization in RCT. # Minimran: a robust online system to implement minimization in randomized clinical trials. Xiao L & Ma J. _JSM Proc_ _Biopharm Section. Alexandria_ _VA: American Statistical Association 2014; 1094-1100._ 2014-08-06 ## Abstract Despite its theoretically and empirically supported appeal for being able to achieve balance allocation across multiple prognostic factors, minimization remains uncommonly used in clinical trials owing to a lack of implementation tools. To fill this gap, we have developed a robust, flexible, and readily accessible Web-based treatment allocation system, MinimRan ( [http://studies.pamfri.org:8080/minimRan/index.jsp](http://studies.pamfri.org:8080/minimRan/index.jsp) ), in order to promote broad adoption of minimization into clinical research practice. The system currently provides the Pocock-Simon, two-way, and symmetric Kullback-Leibler divergence (KLD) minimization methods. It can support single- and double-blind trials as well as single-center and multicenter trials. MinimRan's ability to ensure double-blinding through a sophisticated, nevertheless user-friendly, role management capability distinguishes it from other existing minimization websites. MinimRan also has robust data management and report functions that enable researchers continuously monitor the randomization process, detect, prevent and correct errors, and verify randomization results. This paper will showcase MinimRan's core functionalities and discuss future development. [PubMed abstract](https://ww2.amstat.org/meetings/jsm/2014/onlineprogram/AbstractDetails.cfm?abstractid=311452) ## Research topics - [Biostatistics](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Biostatistics%5C%22%22) - [Comparative Effectiveness](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Comparative+Effectiveness%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Selection bias modeling using observed data augmented with imputed record-level probabilities.](https://www.sutterhealth.org/research/publications/selection-bias-modeling-using-observed-data-1055312921) Thompson CA, Arah OA. Ann Epidemiol. pii: S1047-2797(14)00364-0. doi: 10.1016/j.annepidem.2014.07.014. \[Epub ahead of print\] 2014 Aug 12 - Publication ### [A comparison of two worlds: How does Bayes hold up to the status quo for the analysis of clinical trials?](https://www.sutterhealth.org/research/publications/bayesian-vs-trad-methods-to-analyze-clinical-trials-1055312637) Pressman AR, Avins AL, Hubbard A, Satariano WA. Contemp Clin Trials. 32(4):561-8. doi: 10.1016/j.cct.2011.03.010. Epub 2011 Mar 29. 2011 Jul 01 - Publication ### [Bar charts enhance Bland-Altman plots when value ranges are limited.](https://www.sutterhealth.org/research/publications/bar-charts-enhance-bland-altman-plots-1055312551) Smith MW, Ma J, Stafford RS. J Clin Epidemiol. 63(2):180-4. doi: 10.1016/j.jclinepi.2009.06.001. Epub 2009 Aug 27. 2010 Feb 01 - Publication ### [Comparison of dynamic block randomization and minimization in randomized trials: a simulation study.](https://www.sutterhealth.org/research/publications/block-randomization-minimization-randomized-trials-1055312663) Xiao L, Lavori PW, Wilson SR, Ma J. Clin Trials. 8(1):59-69. doi: 10.1177/1740774510391683. 2011 Feb 01 - Publication ### [Algorithm for balancing both continuous and categorical covariates in randomized controlled trials](https://www.sutterhealth.org/research/publications/algorithm-balancing-covariates-rcts-1055312558) Xiao L, Yank V, Ma J. Comput Methods Programs Biomed. 108(3):1185-90. doi: 10.1016/j.cmpb.2012.06.001. Epub 2012 Jun 22. 2012 Dec 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/minimran-online-do-minimization-rct-1055312971#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Minimran: online system to implement minimization in RCT."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/minimran-online-do-minimization-rct-1055312971#medicalscholarlyarticle","name":"Minimran: a robust online system to implement minimization in randomized clinical trials.","headline":"Minimran: online system to implement minimization in RCT.","abstract":"Despite its theoretically and empirically supported appeal for being able to achieve balance allocation across multiple prognostic factors, minimization remains uncommonly used in clinical trials owing to a lack of implementation tools. 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