--- title: "Monocyte-selective markers: idiopathic pulmonary fibrosis. | Sutter Health" description: "Observations reveal significant differences in cell/molecular markers involved in monocyte/macrophage activation and migration in idiopathic pulmonary fibrosis." url: "https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931" --- 1. [Home](https://www.sutterhealth.org/) / 2. [Research](https://www.sutterhealth.org/research) / 3. [Research publications](https://www.sutterhealth.org/research/publications) / 4. Monocyte-selective markers: idiopathic pulmonary fibrosis. # Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis. Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Maria-Malinao M-C, Li Y, Canfield J, Basham B, de Waal Malefyt R, McClanahan T, Krishna G, & Fick R Jr. _Exp Lung Res. 37(4):227-38. doi: 10.3109/01902148.2010.538132. Epub 2011 Feb 11._ 2011-05-01 ## Abstract Idiopathic interstitial pneumonias are a group of idiopathic interstitial lung diseases of which idiopathic pulmonary fibrosis (IPF) is the lesion of usual interstitial pneumonia. Although the pathogenic mechanisms remain incompletely understood, disease-specific changes in blood, a readily accessible biospecimen, have not been fully characterized. To identify biomarkers from blood and sera, the immune status of IPF patients and control subjects without structural lung disease was quantified by measuring cell surface markers, mRNA levels, and serum proteins. Statistically significant differences in cellular and molecular markers were observed between the 2 groups. The cytokine receptor IL-17RB was significantly higher in CD14+ peripheral blood mononuclear cells (PBMCs) from IPF patients, whereas expression of the chemokine receptor CXCR4 was lower. Gene expression analyses identified 18 differentially expressed genes out of 195 selected. Of these, EMR1, CCR3, UPAR, FCGR2A, OPN, CEACAM3, CD16a, CD18, CD11b, LTF, and LCN2 were up-regulated, whereas IL-17RB, IL-10, PDGFA, CD301/Clec10a, CD25/IL-2RA, IL-23p19, and IL-15 were down-regulated in IPF. Differentially regulated genes were in the functional areas of inflammation and cell signaling. Serum levels of UPAR and OPN were higher in IPF. These observations reveal significant differences in cell and molecular markers involved in monocyte/macrophage activation and migration, and suggest a role for IL-17RB in IPF. [PubMed abstract](http://www.ncbi.nlm.nih.gov/pubmed/?term=Desai+B%2C+Mattson+J%2C+Paintal+H%2C) ![Ganesh Krishna, M.D., FCCP](https://dyn.mktgcdn.com/p/7HZoN6h0d4phO4VQYcU6TE-_Cn72_cBpIS3NRGru51E/fit=crop,gravity=auto,dpr=2,width=188,height=250,quality=100) Ganesh Krishna, M.D., FCCP Principal investigator [View profile](https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082) ## Research topics - [Lung Diseases](https://www.sutterhealth.org/research-search-results?query=%22%5C%22Lung+Diseases%5C%22%22) ## Related publications [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) - Publication ### [Patient dose simulations for scanning-beam digital x-ray tomosynthesis of the lungs.](https://www.sutterhealth.org/research/publications/pt-dose-simulations-sbdx-lung-tomosynthesis-1055312925) Nelson G, Yoon S, Krishna G, Wilfley B, Fahrig R. Med Phys. 40(11):111917. doi: 10.1118/1.4826159. 2013 Nov 01 - Publication ### [Minimally invasive techniques for the diagnosis of peripheral pulmonary nodules.](https://www.sutterhealth.org/research/publications/min-invasive-techniques-peripher-pulm-nodules-1055312945) Krishna G, Gould MK. Curr Opin Pulm Med. 14(4):282-6. doi: 10.1097/MCP.0b013e328303df1b. 2008 Jul 01 - Publication ### [Development of the ATAQ-IPF: A tool to assess quality of life in IPF](https://www.sutterhealth.org/research/publications/development-of-the-ataq-ipf-quality-of-life-1055312581) Swigris JJ, Wilson SR, Green KE, Sprunger DB, Brown KK, Wamboldt FS Health Qual Life Outcomes. 8:77. doi: 10.1186/1477-7525-8-77. 2010 Jul 31 - Publication ### [Nivolumab-induced granulomatous inflammation of the pleura.](https://www.sutterhealth.org/research/publications/nivolumab-induced-granulomat-inflammatn-pleura-1055312317) Benn BS, Lombard CM, Krishna G. J Thorac Oncol. 12(7):e100-e101. doi: 10.1016/j.jtho.2017.03.006. 2017 Jul 01 - Publication ### [The diagnostic yield of navigational bronchoscopy performed with propofol deep sedation.](https://www.sutterhealth.org/research/publications/dx-yield-navigation-bronchoscopy-with-propofol-1055312849) Mohanasundaram U, Ho LA, Kuschner WG, Chitkara RK, Canfield J, Canfield LM, Krishna G. Endoscopy. 2013 (Article ID 824693): 5 pages 2013 Jun 01 [View all publications](https://www.sutterhealth.org/research-search-results?verticalKey=research_publication) ```json {"@context":"https://schema.org","@type":"MedicalOrganization","name":"Sutter Health","@id":"https://www.sutterhealth.org/#medicalorganization","url":"https://www.sutterhealth.org","logo":"https://www.sutterhealth.org/static/images/sutter-health-logo.svg","address":{"@type":"PostalAddress","streetAddress":"2200 River Plaza Drive","addressLocality":"Sacramento","addressRegion":"CA","postalCode":"95833","addressCountry":"US"},"areaServed":{"@type":"AdministrativeArea","name":"California"},"sameAs":["https://www.facebook.com/SutterHealth","https://www.instagram.com/sutterhealth/","https://x.com/SutterHealth","https://www.youtube.com/sutterhealth","https://www.linkedin.com/company/sutter-health","https://en.wikipedia.org/wiki/Sutter_Health"]} ``` ```json {"@context":"https://schema.org","@type":"BreadcrumbList","@id":"https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931#breadcrumblist","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.sutterhealth.org/"},{"@type":"ListItem","position":2,"name":"Research","item":"https://www.sutterhealth.org/research"},{"@type":"ListItem","position":3,"name":"Research publications","item":"https://www.sutterhealth.org/research/publications"},{"@type":"ListItem","position":4,"name":"Monocyte-selective markers: idiopathic pulmonary fibrosis."}]} ``` ```json {"@context":"https://schema.org","@type":"MedicalScholarlyArticle","@id":"https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931#medicalscholarlyarticle","name":"Differential expression of monocyte/macrophage-selective markers in human idiopathic pulmonary fibrosis.","headline":"Monocyte-selective markers: idiopathic pulmonary fibrosis.","abstract":"Idiopathic interstitial pneumonias are a group of idiopathic interstitial lung diseases of which idiopathic pulmonary fibrosis (IPF) is the lesion of usual interstitial pneumonia. Although the pathogenic mechanisms remain incompletely understood, disease-specific changes in blood, a readily accessible biospecimen, have not been fully characterized. To identify biomarkers from blood and sera, the immune status of IPF patients and control subjects without structural lung disease was quantified by measuring cell surface markers, mRNA levels, and serum proteins. Statistically significant differences in cellular and molecular markers were observed between the 2 groups. The cytokine receptor IL-17RB was significantly higher in CD14+ peripheral blood mononuclear cells (PBMCs) from IPF patients, whereas expression of the chemokine receptor CXCR4 was lower. Gene expression analyses identified 18 differentially expressed genes out of 195 selected. Of these, EMR1, CCR3, UPAR, FCGR2A, OPN, CEACAM3, CD16a, CD18, CD11b, LTF, and LCN2 were up-regulated, whereas IL-17RB, IL-10, PDGFA, CD301/Clec10a, CD25/IL-2RA, IL-23p19, and IL-15 were down-regulated in IPF. Differentially regulated genes were in the functional areas of inflammation and cell signaling. Serum levels of UPAR and OPN were higher in IPF. These observations reveal significant differences in cell and molecular markers involved in monocyte/macrophage activation and migration, and suggest a role for IL-17RB in IPF.","description":"Observations reveal significant differences in cell/molecular markers involved in monocyte/macrophage activation and migration in idiopathic pulmonary fibrosis.","keywords":["Lung Diseases"],"datePublished":"2011-05-01","url":"https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931","inLanguage":"en-US","identifier":[{"@type":"PropertyValue","propertyID":"DOI","value":"10.3109/01902148.2010.538132"}],"sameAs":["https://doi.org/10.3109/01902148.2010.538132"],"isPartOf":{"@type":"Periodical","name":"Exp Lung Res"},"author":[{"@type":"Person","name":"Desai B"},{"@type":"Person","name":"Mattson J"},{"@type":"Person","name":"Paintal H"},{"@type":"Person","name":"Nathan M"},{"@type":"Person","name":"Shen F"},{"@type":"Person","name":"Beaumont M"},{"@type":"Person","name":"Maria-Malinao M-C"},{"@type":"Person","name":"Li Y"},{"@type":"Person","name":"Canfield J"},{"@type":"Person","name":"Basham B"},{"@type":"Person","name":"de Waal Malefyt R"},{"@type":"Person","name":"McClanahan T"},{"@type":"Person","@id":"https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082","name":"Krishna G","url":"https://www.sutterhealth.org/research/investigators/ganesh-krishna-md-fccp-1049681082"},{"@type":"Person","name":"Fick R Jr"}],"sourceOrganization":{"@type":"MedicalOrganization","name":"Palo Alto Medical Foundation Research Institute"},"about":[{"@type":"DefinedTerm","name":"Lung Diseases","url":"https://www.sutterhealth.org/research-search-results?facets=%5B%7B%22i%22%3A%22c_researchTopics.name%22%2C%22v%22%3A%5B%22Lung+Diseases%22%5D%7D%5D&verticalKey=research_publication"}],"mainEntityOfPage":{"@type":"WebPage","@id":"https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931","breadcrumb":{"@id":"https://www.sutterhealth.org/research/publications/monocyte-selective-markers-idiopath-pulm-fibrosis-1055312931#breadcrumblist"}}} ```